About: Infectome: A platform to trace infectious triggers of autoimmunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectome: A platform to trace infectious triggers of autoimmunity
Creator	Shoenfeld, Yehuda Blank, Miri Invernizzi, Pietro Pouria, Shideh Smyk, Daniel Bogdanos, Dimitrios Rigopoulou, Eirini
Source	Elsevier; Medline; PMC
abstract	The “exposome” is a term recently used to describe all environmental factors, both exogenous and endogenous, which we are exposed to in a lifetime. It represents an important tool in the study of autoimmunity, complementing classical immunological research tools and cutting-edge genome wide association studies (GWAS). Recently, environmental wide association studies (EWAS) investigated the effect of environment in the development of diseases. Environmental triggers are largely subdivided into infectious and non-infectious agents. In this review, we introduce the concept of the “infectome”, which is the part of the exposome referring to the collection of an individual's exposures to infectious agents. The infectome directly relates to geoepidemiological, serological and molecular evidence of the co-occurrence of several infectious agents associated with autoimmune diseases that may provide hints for the triggering factors responsible for the pathogenesis of autoimmunity. We discuss the implications that the investigation of the infectome may have for the understanding of microbial/host interactions in autoimmune diseases with long, pre-clinical phases. It may also contribute to the concept of the human body as a superorganism where the microbiome is part of the whole organism, as can be seen with mitochondria which existed as microbes prior to becoming organelles in eukaryotic cells of multicellular organisms over time. A similar argument can now be made in regard to normal intestinal flora, living in symbiosis within the host. We also provide practical examples as to how we can characterise and measure the totality of a disease-specific infectome, based on the experimental approaches employed from the “immunome” and “microbiome” projects.
has issue date	2012-12-22(xsd:dateTime)
bibo:doi	10.1016/j.autrev.2012.12.005
bibo:pmid	23266520
has license	no-cc
sha1sum (hex)	1f0ab2bee5fde00f2e1a9a2abd5bc05267d23f7d
schema:url	https://doi.org/10.1016/j.autrev.2012.12.005
resource representing a document's title	Infectome: A platform to trace infectious triggers of autoimmunity
has PubMed Central identifier	PMC7105216
has PubMed identifier	23266520
schema:publication	Autoimmun Rev
resource representing a document's body	covid:1f0ab2bee5fde00f2e1a9a2abd5bc05267d23f7d#body_text
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