About: Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery
Creator	Cristofori-Armstrong, Ben Herzig, Herzig, Volker Israel, Mathilde King, Glenn Nixon, Samantha Vetter, Irina
Source	Elsevier; Medline; PMC
abstract	Venomous animals have evolved toxins that interfere with specific components of their victim’s core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other roles such as intraspecific competition. Many animal lineages evolved venom systems independently, highlighting the success of this strategy. Over the course of evolution, toxins with exceptional specificity and high potency for their intended molecular targets have prevailed, making venoms an invaluable and almost inexhaustible source of bioactive molecules, some of which have found use as pharmacological tools, human therapeutics, and bioinsecticides. Current biomedically-focused research on venoms is directed towards their use in delineating the physiological role of toxin molecular targets such as ion channels and receptors, studying or treating human diseases, targeting vectors of human diseases, and treating microbial and parasitic infections. We provide examples of each of these areas of venom research, highlighting the potential that venom molecules hold for basic research and drug development.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1016/j.bcp.2020.114096
bibo:pmid	32535105
has license	no-cc
sha1sum (hex)	1f48116bf168b6963087c38bd31783c1a2864696
schema:url	https://doi.org/10.1016/j.bcp.2020.114096
resource representing a document's title	Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery
has PubMed Central identifier	PMC7290223
has PubMed identifier	32535105
schema:publication	Biochem Pharmacol
resource representing a document's body	covid:1f48116bf168b6963087c38bd31783c1a2864696#body_text
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