About: Association of TNF-α –308G/A, SP-B 1580 C/T, IL-13 –1055 C/T gene polymorphisms and latent adenoviral infection with chronic obstructive pulmonary disease in an Egyptian population

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About: Association of TNF-α –308G/A, SP-B 1580 C/T, IL-13 –1055 C/T gene polymorphisms and latent adenoviral infection with chronic obstructive pulmonary disease in an Egyptian population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of TNF-α –308G/A, SP-B 1580 C/T, IL-13 –1055 C/T gene polymorphisms and latent adenoviral infection with chronic obstructive pulmonary disease in an Egyptian population
Creator	Ezzeldin, Howayda Ezzeldin, Nada Farouk, Hebatallah Saad-Hussein, Amal Shalaby, Alaa Kandil, Dina Lebedy, Dalia
Source	Medline; PMC
abstract	INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death. The most common cause of COPD is smoking. There is evidence suggesting that genetic factors influence COPD susceptibility and variants in several candidate genes have been significantly associated with COPD. In this study, we aimed to investigate the possible association of the TNF-α –308, SPB+1580, IL-13 –1055 gene polymorphisms and latent adenovirus C infection with COPD in an Egyptian population. MATERIAL AND METHODS: Our study included 115 subjects (75 smokers with COPD, 25 resistant smokers and 15 non-smokers) who were subjected to spirometric measurements, identification of adenovirus C and genotyping of TNF-α –308G/A, SP-B+1580 C/T and IL-13 –1055 C/T polymorphisms by real-time PCR. RESULTS: The adenovirus C gene was identified in all subjects. The distribution of TNF-α genotypes showed no significant differences between different groups. However, homozygous A genotype was associated with a significant decrease in FEV(1), FEV(1)/FVC and FEF25/75% of predicted in COPD (p < 0.05). As regards SP-B genotypes, resistant smokers had a significantly higher homozygous T genotype frequency compared to COPD and non smokers (p = 0.005). Interleukin 13 genotypes showed no significant difference between different groups. There was a significant decrease in FEF25/75% of predicted in T allele carriers in COPD patients (p = 0.001). CONCLUSIONS: The COPD is a disease caused by the interaction of combined genes and environmental influences, in the presence of smoking and latent adenovirus C infection, TNF-α –308A, SPB +1580 T and IL-13 –1055 T polymorphisms predispose to the development of COPD.
has issue date	2012-05-09(xsd:dateTime)
bibo:doi	10.5114/aoms.2012.28556
bibo:pmid	22662002
has license	cc-by-nc-nd
sha1sum (hex)	1f541a086ac9bc30df8ee2060f958691fb4a0667
schema:url	https://doi.org/10.5114/aoms.2012.28556
resource representing a document's title	Association of TNF-α –308G/A, SP-B 1580 C/T, IL-13 –1055 C/T gene polymorphisms and latent adenoviral infection with chronic obstructive pulmonary disease in an Egyptian population
has PubMed Central identifier	PMC3361041
has PubMed identifier	22662002
schema:publication	Arch Med Sci
resource representing a document's body	covid:1f541a086ac9bc30df8ee2060f958691fb4a0667#body_text
is schema:about of	named entity 'VARIANTS' named entity 'INFECTION' named entity '115' named entity 'INTRODUCTION' named entity 'SMOKERS' named entity 'IL-13' named entity 'RESISTANT' named entity 'GENOTYPE' named entity 'PRESENCE OF' named entity 'ASSOCIATION' named entity 'NON-SMOKERS' named entity 'RESULTS' named entity 'GENETIC FACTORS' named entity 'GENOTYPING' named entity 'CANDIDATE GENES' named entity '308' named entity 'FREQUENCY' named entity 'DEATH' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'GENOTYPES' named entity 'ASSOCIATED WITH' named entity 'COMMON' named entity 'Introduction' named entity 'caused' named entity 'FVC' named entity 'Results' named entity 'COPD' named entity 'There' named entity 'leading' named entity 'disability' named entity 'IL-13' named entity 'MATERIAL' named entity '1055' named entity 'FEV 1' named entity 'COMBINED' named entity 'POPULATION' named entity 'ASSOCIATION' named entity 'DECREASE' named entity 'C GENE' named entity '0.005' named entity 'STUDY' named entity 'METHODS' named entity 'SMOKING' named entity 'LEADING' named entity 'SPB' named entity 'ADENOVIRAL INFECTION' named entity 'GENE POLYMORPHISMS' named entity 'LATENT' named entity 'SP-B' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'GROUPS' named entity 'WAS A' named entity 'DISTRIBUTION' named entity 'IS A' named entity 'INCLUDED' named entity 'GENES' named entity 'COPD' named entity '0.001' named entity 'SIGNIFICANT' named entity 'MEASUREMENTS' named entity 'PATIENTS' named entity 'INTERACTION' named entity 'FACTORS INFLUENCE' named entity 'SUSCEPTIBILITY' named entity 'EVIDENCE' named entity 'IDENTIFIED' named entity 'PREDICTED' named entity 'DISABILITY' named entity 'ENVIRONMENTAL' named entity 'ALL SUBJECTS' named entity 'POPULATION' named entity 'HAVE' named entity 'HOMOZYGOUS' named entity 'SP-B' named entity 'CARRIERS'

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