About: Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
Creator	Peters, Bjoern Sette, Alessandro Krammer, Florian Grifoni, Alba Sutherland, S Carlin, Aaron De Silva, Aravinda Jadi, Ramesh Smith, Davey Smith, F Ramirez, Sydney Greenbaum, Jason Authors, Alba Crotty, Shane Crotty, D Dan, Jennifer Frazier, A Frazier, April Grifoni, Grifoni, A Jadi, L Marrama, Daniel Marrama, R Mateus, Jose Moderbacher, Carolyn Premkumar, Lakshmanane Rawlings, Stephen Rawlings, C Sette, S Sutherland, Aaron Weiskopf, Daniela Weiskopf, D
Source	Elsevier; Medline; PMC
abstract	Summary Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike and N proteins each accounted for 11-27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2−reactive CD4+ T cells in ∼40-60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.05.015
bibo:pmid	32473127
has license	els-covid
sha1sum (hex)	1f65e3f5e56789880e2e5b38b3876d688fbdfb53
schema:url	https://doi.org/10.1016/j.cell.2020.05.015
resource representing a document's title	Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
has PubMed Central identifier	PMC7237901
has PubMed identifier	32473127
schema:publication	Cell
resource representing a document's body	covid:1f65e3f5e56789880e2e5b38b3876d688fbdfb53#body_text
is schema:about of	named entity 'cross-reactive' named entity 'vaccine' named entity 'class I' named entity 'immunity' named entity 'coronaviruses' named entity 'SARS-CoV-2' named entity 'adaptive' named entity 'T cells' named entity 'targeting' named entity 'pandemic' named entity 'convalescent' named entity 'T cell' named entity 'spike' named entity 'identified' named entity 'Understanding' named entity 'peptide' named entity 'SARS-CoV-2' named entity 'common cold' named entity 'CD8 +' named entity 'SARS-CoV-2' named entity 'cell recognition' named entity 'IgA' named entity 'COVID' named entity 'coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'CD4 +' named entity 'peptide' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'nsp4' named entity 'nsp3' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'coronavirus' named entity 'URI' named entity 'St. Louis' named entity 'CD4 +' named entity 'SARS-CoV-2' named entity 'CD8 +' named entity 'cryopreserved' named entity 'acute respiratory distress syndrome' named entity 'peptides' named entity 'immune response' named entity 'nsp6' named entity 'positive and negative controls' named entity 'peptides' named entity 'toxicity' named entity 'CD8 +' named entity 'malignancy'

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