About: A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
Creator	Proll, Sean Galagan, James Aderem, Alan Ansong, Charles Kaiser, Shari Rosenberger, Carrie Schoolnik, Gary Adkins, Joshua Katze, Michael Korth, Marcus Law, G Mcdermott, Jason
Source	Medline; PMC
abstract	The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.
has issue date	2011-02-01(xsd:dateTime)
bibo:doi	10.1128/mbio.00325-10
bibo:pmid	21285433
has license	cc-by-nc-sa
sha1sum (hex)	1f71a8f9029056b6e7656ebd885ccce476e2f623
schema:url	https://doi.org/10.1128/mbio.00325-10
resource representing a document's title	A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
has PubMed Central identifier	PMC3034460
has PubMed identifier	21285433
schema:publication	mBio
resource representing a document's body	covid:1f71a8f9029056b6e7656ebd885ccce476e2f623#body_text
is schema:about of	named entity 'SYSTEMS' named entity 'MICROBES' named entity 'NEARLY' named entity 'APPROACHES' named entity 'VIEWS' named entity 'SUFFICIENT' named entity 'HAVE' named entity 'NEEDED' named entity 'UNDERSTANDING' named entity 'METHODS' named entity 'SYSTEMS BIOLOGY' named entity 'FOCUS' named entity 'INCLUDING' named entity 'PROTEINS' named entity 'SEEN' named entity 'RESEARCH' named entity 'ADVANTAGE' named entity 'HAND' named entity 'VACCINES' named entity 'full' named entity 'Paradigm' named entity 'INFECTIOUS DISEASE RESEARCH' named entity 'TOOLS' named entity 'NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES' named entity 'PARADIGM' named entity 'PANDEMICS' named entity 'HOST' named entity 'CENTURY' named entity 'DECADE' named entity 'GENES' named entity 'THINK' named entity 'APPROACH' named entity 'SYSTEMS BIOLOGY' named entity 'RESEARCH' named entity 'PATHOGEN' named entity 'TYPICAL' named entity 'RECENTLY' named entity 'COMPREHENSIVE' named entity 'MOLECULAR BIOLOGY' named entity 'TECHNOLOGY' named entity 'RESISTANT' named entity 'TO TAKE' named entity 'WATERBORNE' named entity 'BIOLOGICAL' named entity 'INDIVIDUAL' named entity 'FREQUENT' named entity 'COMPUTATIONAL' named entity 'PROVIDE' named entity 'HOST' named entity 'DRUGS' named entity 'ADDRESS' named entity 'INFECTIOUS DISEASE' named entity 'TWENTY' named entity 'ILLNESSES' named entity 'RISE' named entity 'PARTICIPANTS' named entity 'PARADIGM' named entity 'NEW' named entity 'CHALLENGES' named entity 'TIME' named entity 'BUT' named entity 'INFECTIOUS DISEASE RESEARCH' named entity 'THESE' named entity 'MARKED' named entity 'INTENSE' named entity 'PATHOGEN' named entity 'SCIENTIFIC' named entity 'FOOD' named entity 'PROGRAM' named entity 'PAST'

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