About: Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling

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About: Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling
Creator	Chen, Huan Wang, Min He, Rong-Rong Jie, Chong Kurihara, Hiroshi Li, Yi-Fang Luo, Zhuo Mao, Zhong-Fu Xiao, Gao-Keng Yan, Chang
Source	Medline; PMC
abstract	Isatis indigotica has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targeting host factors, such as type I interferon production. In this study, this model was employed to investigate the effect and mechanism of indirubin, a natural bisindole alkaloid from Isatis indigotica, on influenza A virus susceptibility. In the in vitro study, the stress hormone corticosterone was used to simulate restraint stress. Our results demonstrated that indirubin decreased the susceptibility to influenza virus with lowered mortality and alleviated lung damage in restraint-stressed mice model. Moreover, indirubin promoted the expression of interferon-β and interferon inducible transmembrane 3. In addition, indirubin maintained the morphology and function of mitochondria following influenza A virus infection. Further study revealed that indirubin promoted interferon-β production through promoting mitochondrial antiviral signaling pathway. Our study indicated that indirubin could be a candidate for the therapy of influenza.
has issue date	2017-11-09(xsd:dateTime)
bibo:doi	10.18632/oncotarget.22350
bibo:pmid	29285277
has license	cc-by
sha1sum (hex)	1f7224df292f2dcbfb805602296acd9aba317f24
schema:url	https://doi.org/10.18632/oncotarget.22350
resource representing a document's title	Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling
has PubMed Central identifier	PMC5739664
has PubMed identifier	29285277
schema:publication	Oncotarget
resource representing a document's body	covid:1f7224df292f2dcbfb805602296acd9aba317f24#body_text
is schema:about of	named entity 'targeting' named entity 'mortality' named entity 'production' named entity 'virus' named entity 'H1N1' named entity 'MICE' named entity 'ITS' named entity 'LOWERED' named entity 'USED' named entity 'EFFECT' named entity 'TO INVESTIGATE' named entity 'EVIDENCE' named entity 'H1N1' named entity 'SUSCEPTIBILITY' named entity 'EVALUATING' named entity 'MECHANISM' named entity 'MAINTAINED' named entity 'EMPLOYED' named entity 'ADDITION' named entity 'LUNG' named entity 'MITOCHONDRIAL' named entity 'INFLUENZA VIRUS' named entity 'INDICATED' named entity 'VIRUS' named entity 'APPROPRIATE' named entity 'PRODUCTION' named entity 'STUDY' named entity 'TYPE I INTERFERON PRODUCTION' named entity 'DAMAGE' named entity 'ESTABLISH' named entity 'SATISFACTORY' named entity 'RESULTS' named entity 'MORPHOLOGY' named entity 'RESTRAINT' named entity 'FOLLOWING' named entity 'INDUCIBLE' named entity 'INTERFERON' named entity 'ANIMAL STUDIES' named entity 'NATURAL' named entity 'LACK' named entity 'INDIRUBIN' named entity 'ISATIS INDIGOTICA' named entity 'VIRUS SUSCEPTIBILITY' named entity 'SUSCEPTIBILITY' named entity 'FUNCTION' named entity 'DEMONSTRATED' named entity 'BISINDOLE ALKALOID' named entity 'STRESSED' named entity 'SIGNALING PATHWAY' named entity 'PROMOTING' named entity 'MOUSE' named entity 'INFLUENZA A VIRUS' named entity 'DECREASED' named entity 'ANIMAL MODEL' named entity 'PREVIOUSLY' named entity 'REGULATING' named entity 'MIGHT BE' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'STRESSED' named entity 'INDIRUBIN' named entity 'ISATIS INDIGOTICA' named entity 'HOST' named entity 'MORTALITY' named entity 'TRANSMEMBRANE' named entity 'STRESS HORMONE' named entity 'IN VITRO STUDY' named entity 'INFLUENZA' named entity 'ANTIVIRAL' named entity 'SIMULATE' named entity 'TARGETING' named entity 'REVEALED' named entity 'MODEL'

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