About: Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

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About: Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
Creator	Jia, Wenxu Wang, Xinquan Zhang, Linqi Zhang, Senyan Niu, Peihua Tan, Wenjie Huang, Baoying Zhang, Shuyuan Zhou, Haixia Chen, Yingzhu Lan, Jun Qin, Kun
Source	Medline; PMC
abstract	Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). The epitopes and mechanisms of mAbs targeting non-RBD regions have not been well characterized yet. Here we report the monoclonal antibody 7D10 that binds to the N-terminal domain (NTD) of the spike glycoprotein and inhibits the cell entry of MERS-CoV with high potency. Structure determination and mutagenesis experiments reveal the epitope and critical residues on the NTD for 7D10 binding and neutralization. Further experiments indicate that the neutralization by 7D10 is not solely dependent on the inhibition of DPP4 binding, but also acts after viral cell attachment, inhibiting the pre-fusion to post-fusion conformational change of the spike. These properties give 7D10 a wide neutralization breadth and help explain its synergistic effects with several RBD-targeting antibodies.
has issue date	2019-07-11(xsd:dateTime)
bibo:doi	10.1038/s41467-019-10897-4
bibo:pmid	31296843
has license	cc-by
sha1sum (hex)	1fb860b35fac03bc319a2d12de832b65ca392c55
schema:url	https://doi.org/10.1038/s41467-019-10897-4
resource representing a document's title	Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
has PubMed Central identifier	PMC6624210
has PubMed identifier	31296843
schema:publication	Nat Commun
resource representing a document's body	covid:1fb860b35fac03bc319a2d12de832b65ca392c55#body_text
is schema:about of	named entity 'binding' named entity 'Further' named entity 'residues' named entity 'viral' named entity 'neutralization' named entity 'block' named entity 'neutralization' named entity 'NEUTRALIZATION ' named entity 'REGIONS' named entity 'HERE' named entity 'ENTRY' named entity 'INHIBITING' named entity 'REVEAL' named entity 'RECEPTOR' named entity 'NEUTRALIZATION ' named entity 'STRUCTURE DETERMINATION' named entity 'RBD' named entity 'BLOCK' named entity 'DIPEPTIDYL PEPTIDASE 4' named entity 'POST' named entity 'DEPENDENT' named entity 'EXPERIMENTS' named entity 'CHARACTERIZED' named entity 'CELLULAR' named entity 'DOMAIN' named entity 'BREADTH' named entity 'FUSION' named entity 'HELP' named entity 'MECHANISMS' named entity 'EFFECTS' named entity 'TARGET' named entity 'HIGH' named entity 'NTD' named entity 'THE CELL' named entity 'EPITOPES' named entity 'ITS' named entity 'PRE' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'N-TERMINAL ' named entity 'N-TERMINAL ' named entity 'ANTIBODIES' named entity 'REPORT' named entity 'SYNERGISTIC' named entity 'MUTAGENESIS' named entity 'NON-' named entity 'POTENCY' covid:arg/1fb860b35fac03bc319a2d12de832b65ca392c55 named entity 'INHIBITION' named entity 'EPITOPE' named entity 'DEFINITION' named entity 'MERS-COV' named entity 'CONFORMATIONAL CHANGE' named entity 'BUT' named entity 'VIRAL' named entity 'HAVE' named entity 'WIDE' named entity 'CELL ATTACHMENT' named entity 'TARGETING' named entity 'NEUTRALIZING ANTIBODIES' named entity 'NEUTRALIZATION' named entity 'MONOCLONAL ANTIBODY' named entity 'EPITOPE' named entity 'ACTS' named entity 'BINDING' named entity 'DPP4' named entity 'STRUCTURAL' named entity 'DOMAIN' named entity 'CRITICAL' named entity 'THESE' named entity 'PROPERTIES'

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