About: Impact of bacterial colonization on the severity, and accompanying airway inflammation, of virus-induced wheezing in children

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About: Impact of bacterial colonization on the severity, and accompanying airway inflammation, of virus-induced wheezing in children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of bacterial colonization on the severity, and accompanying airway inflammation, of virus-induced wheezing in children
Creator	Wei, L Enmei, L Jian, L Lijia, W Xiaodong, Z Xiqiang, Y Yu, D Zhengxiu, L Zhou, F
Source	PMC
abstract	It is reported that bacterial colonization of the airway in neonates affects the likelihood and severity of subsequent wheezing in childhood. This study aimed to explore the impact of bacterial colonization on the severity of virus-induced wheezing, and accompanying airway inflammation. Nasopharyngeal aspirates (NPAs) from 68 hospitalized children with bronchiolitis and 85 children with recurrent wheezing were obtained. Eleven common respiratory viruses were sought by PCR and/or direct fluorescence assay. Bacteria were isolated from NPAs by routine culture methods. Cell numbers and concentrations of cytokines/chemokines in the NPAs were measured, and nucleated cells were characterized. The frequency of bacterial colonization in children with recurrent wheezing was significantly higher than in children with an initial attack of bronchiolitis. Bacterial colonization accompanying virus infection had no effect on clinical manifestations, duration of hospitalization, concentrations of cytokines/chemokines (except interleukin-10 (IL-10)) or cellularity in the children with bronchiolitis; however, among the children with recurrent wheezing, those who had coexistent non-invasive bacterial colonization and virus infection presented more frequent cyanosis, longer duration of hospitalization, a higher concentration of IL-10 and a higher percentage of neutrophils in NPAs than those with virus infection but without bacterial colonization. Bacterial colonization was common in children with virus-induced wheezing, particularly in the situation of recurrent wheezing. To some extent, bacterial colonization accompanying virus infection may contribute to the severity of the wheezing because of its impact on airway inflammation.
has issue date	2014-12-12(xsd:dateTime)
bibo:doi	10.1111/j.1469-0691.2010.03147.x
bibo:pmid	20041894
has license	no-cc
sha1sum (hex)	20174a0a241b83eafe67f99aed68cb0f165b9f11
schema:url	https://doi.org/10.1111/j.1469-0691.2010.03147.x
resource representing a document's title	Impact of bacterial colonization on the severity, and accompanying airway inflammation, of virus-induced wheezing in children
has PubMed Central identifier	PMC7128791
has PubMed identifier	20041894
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:20174a0a241b83eafe67f99aed68cb0f165b9f11#body_text
is schema:about of	named entity 'NPAs' named entity 'NPAs' named entity 'colonization' named entity 'bacterial' named entity 'virus' named entity 'infection' named entity 'PCR' named entity 'IMPACT' named entity 'ACCOMPANYING' named entity 'PRESENTED' named entity 'NEUTROPHILS' named entity 'NASOPHARYNGEAL' named entity 'DIRECT' named entity 'CELLULARITY' named entity 'NON-INVASIVE' named entity 'METHODS' named entity 'FLUORESCENCE ASSAY' named entity 'CHILDHOOD' named entity 'CLINICAL MANIFESTATIONS' named entity 'AIRWAY INFLAMMATION' named entity 'OBTAINED' named entity 'DURATION OF HOSPITALIZATION' named entity 'nucleated' named entity 'colonization' named entity 'accompanying' named entity 'inflammation' named entity 'higher' named entity 'virus' named entity 'cytokines' named entity 'wheezing' named entity 'concentrations' named entity 'chemokines' named entity 'cells' named entity 'infection' named entity 'accompanying' named entity 'bacterial colonization' named entity 'virus infection' named entity 'Nasopharyngeal' named entity 'wheezing' named entity 'virus' named entity 'virus' named entity 'bronchiolitis' named entity 'bacterial colonization' named entity 'chemokines' named entity 'neonates' named entity 'wheezing' named entity 'cyanosis' named entity 'IL-10' named entity 'PCR' named entity 'virus' named entity 'bacterial colonization' named entity 'wheezing' named entity 'Cell' named entity 'chemokine' named entity 'Zhuhai' named entity 'interleukin-10' named entity 'cytokines' named entity 'pure culture' named entity 'bacterial colonization' named entity 'virus infection' named entity 'sinusitis' named entity 'sputum' named entity 'informed consent' named entity 'IL-10' named entity 'standard curve' named entity 'wheezing' named entity 'China' named entity 'clinical significance' named entity 'influenza A virus' named entity 'IL-10' named entity 'bacterial colonization' named entity 'interleukin-8' named entity 'influenza A virus'

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