About: Minireview The influence of season, photoperiod, and pineal melatonin on immune function

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Minireview The influence of season, photoperiod, and pineal melatonin on immune function
Creator	Klein, Sabra Demas, Gregory Ge, Demas Kriegsfeld, L Kriegsfeld, Lance Nelson, Randy Rj, Nelson Sl, Klein
source	PMC
abstract	Abstract: In addition to the well‐documented seasonal cycles of mating and birth, there are also significant seasonal cycles of illness and death among many animal populations. Challenging winter conditions (i.e., low ambient temperature and decreased food availability) can directly induce death via hypothermia, starvation, or shock. Coping with these challenges can also indirectly increase morbidity and mortality by increasing glucocorticoid secretion, which can compromise immune function. Many environmental challenges are recurrent and thus predictable; animals could enhance survival, and presumably increase fitness, if they could anticipate immunologically challenging conditions in order to cope with these seasonal threats to health. The annual cycle of changing photoperiod provides an accurate indicator of time of year and thus allows immunological adjustments prior to the deterioration of conditions. Pineal melatonin codes day length information. Short day lengths enhance several aspects of immune function in laboratory studies, and melatonin appears to mediate many of the enhanced immunological effects of photoperiod. Generally, field studies report compromised immune function during the short days of autumn and winter. The conflict between laboratory and field data is addressed with a multifactor approach. The evidence for seasonal fluctuations in lymphatic tissue size and structure, as well as immune function and disease processes, is reviewed. The role of pineal melatonin and the hormones regulated by melatonin is discussed from an evolutionary and adaptive functional perspective. Finally, the clinical significance of seasonal fluctuations in immune function is presented. Taken together, it appears that seasonal fluctuations in immune parameters, mediated by melatonin, could have profound effects on the etiology and progression of diseases in humans and nonhuman animals. An adaptive functional perspective is critical to gain insights into the interaction among melatonin, immune function, and disease processes.
has issue date	2007-01-30(xsd:dateTime)
bibo:doi	10.1111/j.1600-079x.1995.tb00184.x
bibo:pmid	8789246
has license	no-cc
sha1sum (hex)	2026fae2351a8f19c31febc573e7ea6b7a51af9a
schema:url	https://doi.org/10.1111/j.1600-079x.1995.tb00184.x
resource representing a document's title	Minireview The influence of season, photoperiod, and pineal melatonin on immune function
has PubMed Central identifier	PMC7166827
has PubMed identifier	8789246
schema:publication	J Pineal Res
resource representing a document's body	covid:2026fae2351a8f19c31febc573e7ea6b7a51af9a#body_text
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