About: The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada

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About: The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada
Creator	Smieja, Marek Simor, Andrew Gubbay, Jonathan Richardson, Susan Katz, Kevin Campigotto, Aaron Karnauchow, Timothy Buchan, Sarah Crowcroft, Natasha Kwong, Jeff Kwong, Jeffrey Mcgeer, Allison Rosella, Laura Schwartz, Kevin Aaron, Campigotto Andrew, Simor Campitelli¹, Michael Chung¹, Hannah David, Richardson Dayre, J George, Zahariadis Gubbay, Natasha Hannah, Chung Kevin, Katz Kh Jung¹, James Kh, Jung Laura, Rosella Marek, Smieja Mcnally, Allison Mcnally, Dayre Richardson, David Richardson, C Timothy, Karnauchow
Source	PMC
abstract	INTRODUCTION: Annual influenza vaccination is recommended for older adults, but evidence regarding the impact of repeated vaccination has been inconclusive. AIM: We investigated vaccine effectiveness (VE) against laboratory-confirmed influenza and the impact of repeated vaccination over 10 previous seasons on current season VE among older adults. METHODS: We conducted an observational test-negative study in community-dwelling adults aged > 65 years in Ontario, Canada for the 2010/11 to 2015/16 seasons by linking laboratory and health administrative data. We estimated VE using multivariable logistic regression. We assessed the impact of repeated vaccination by stratifying by previous vaccination history. RESULTS: We included 58,304 testing episodes for respiratory viruses, with 11,496 (20%) testing positive for influenza and 31,004 (53%) vaccinated. Adjusted VE against laboratory-confirmed influenza for the six seasons combined was 21% (95% confidence interval (CI): 18 to 24%). Patients who were vaccinated in the current season, but had received no vaccinations in the previous 10 seasons, had higher current season VE (34%; 95%CI: 9 to 52%) than patients who had received 1–3 (26%; 95%CI: 13 to 37%), 4–6 (24%; 95%CI: 15 to 33%), 7–8 (13%; 95%CI: 2 to 22%), or 9–10 (7%; 95%CI: −4 to 16%) vaccinations (trend test p = 0.001). All estimates were higher after correcting for misclassification of current season vaccination status. For patients who were not vaccinated in the current season, residual protection rose significantly with increasing numbers of vaccinations received previously. CONCLUSIONS: Although VE appeared to decrease with increasing numbers of previous vaccinations, current season vaccination likely provides some protection against influenza regardless of the number of vaccinations received over the previous 10 influenza seasons.
has issue date	2020-01-09(xsd:dateTime)
bibo:doi	10.2807/1560-7917.es.2020.25.1.1900245
bibo:pmid	31937397
has license	cc-by
sha1sum (hex)	20317b47f1178792d735b4202fc343721d1ff4a5
schema:url	https://doi.org/10.2807/1560-7917.es.2020.25.1.1900245
resource representing a document's title	The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada
has PubMed Central identifier	PMC6961264
has PubMed identifier	31937397
schema:publication	Euro Surveill
resource representing a document's body	covid:20317b47f1178792d735b4202fc343721d1ff4a5#body_text
is schema:about of	named entity 'SEASONS' named entity 'CANADA' named entity 'INFLUENZA' named entity 'ONTARIO' named entity 'influenza' named entity 'older adults' named entity 'PCR' named entity 'vaccination' named entity 'Austria' named entity 'OHIP' named entity 'comorbidity' named entity 'vaccination' named entity 'pharmacist' named entity 'vaccination' named entity 'sensitivity and specificity' named entity 'vaccine' named entity 'RCT' named entity 'subgroup analyses' named entity 'Vaccine' named entity 'influenza' named entity 'influenza' named entity 'virus' named entity 'influenza' named entity 'vaccination' named entity 'vaccine' named entity '0.01' named entity 'H3N2' named entity 'influenza' named entity 'antigens' named entity 'vaccine' named entity 'Ontario' named entity 'older adults' named entity 'study population' named entity 'cross-reactivity' named entity 'uniform distribution' named entity 'RCT' named entity 'immune responses' named entity 'prescription medications' named entity 'health insurance' named entity 'sensitivity analysis' named entity 'vaccination' named entity 'influenza' named entity 'health insurance' named entity 'influenza vaccination' named entity 'higher risk' named entity 'SAS' named entity 'influenza infection' named entity 'Ontario' named entity 'vaccination'

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