About: Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV
Creator	Oliveira, M Amâncio, R Cerbino-Neto, J Dm Costa, Fa Bozza, Japiassu, A Pecego, A Siqueira, M
Source	Medline; PMC
abstract	People living with HIV (PLWH) are more prone to severe respiratory infections. We used the severe acute respiratory infection (SARI) definition to describe the etiology, clinical, and epidemiological characteristics in this population. This was a prospective observational study including PLWH hospitalized with fever and cough. Those with symptom onset up to 10 days were classified as severe acute respiratory infection and 11–30 days as non-severe acute respiratory infection. Blood, urine samples and nasopharyngeal swabs were collected. Data were extracted from patient charts during their hospital stay. Forty-nine patients were included, median CD4 cell count: 80 cells/mm(3), median time since HIV diagnosis and hospital admission: 84 months and 80% were antiretroviral therapy exposed. Twenty-seven patients were classified as SARI. Etiology was identified in 69%, 47% were polymicrobial. Respiratory virus (9 SARI vs. 13 non-SARI), bacteria (5 SARI vs. 4 non-SARI), Mycobacterium tuberculosis (6 SARI group vs. 7 non-SARI group), Pneumocystis jirovecii (4 SARI vs. 1 non-SARI), Cryptococcus neoformans (1 SARI vs. 3 non-SARI), and influenza A (1 SARI vs. 2 non-SARI). Dyspnea was statistically more prevalent in SARI (78% vs. 36%, p = 0.011) but the risk of death was higher in the non-SARI (4% vs. 36%, p = 0.0067). In the severely immunocompromised PLWH, severe acute respiratory infection can be caused by multiple pathogens and codetection is a common feature.
has issue date	2020-01-22(xsd:dateTime)
bibo:doi	10.1177/0956462419882587
bibo:pmid	31969059
has license	cc-by
sha1sum (hex)	2053a7c291fe201dca926318490a8ae645141684
schema:url	https://doi.org/10.1177/0956462419882587
resource representing a document's title	Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV
has PubMed Central identifier	PMC7206327
has PubMed identifier	31969059
schema:publication	Int J STD AIDS
resource representing a document's body	covid:2053a7c291fe201dca926318490a8ae645141684#body_text
is schema:about of	named entity 'higher' named entity 'HIV' named entity 'symptom' named entity 'exposed' named entity 'onset' named entity 'median' named entity 'fever' named entity 'Blood' named entity 'admission' named entity 'Etiology' named entity '80%' named entity 'CRYPTOCOCCUS NEOFORMANS' named entity 'TWENTY-SEVEN' named entity 'DAYS' named entity 'USED' named entity 'immunocompromised' named entity 'patient' named entity 'etiology' named entity 'diagnosis' named entity 'influenza A' named entity 'pneumonia' named entity 'ICU' named entity 'WHO' named entity 'pathogens' named entity 'SARI' named entity 'odynophagia' named entity 'nasopharyngeal' named entity 'pathogens' named entity 'CD4 cell count' named entity 'SARI' named entity 'SARI' named entity 'SARI' named entity 'Dyspnea' named entity 'fever' named entity 'bacteria' named entity 'SARI' named entity 'pathogens' named entity 'Pneumocystis jirovecii' named entity 'SARI' named entity 'epidemiological' named entity 'viruses' named entity 'CRB' named entity 'L. pneumophila' named entity 'cough' named entity 'respiratory frequency' named entity 'epidemiological' named entity 'CAP' named entity '10.5' named entity 'PCR technique' named entity 'HIV-positive' named entity 'bacterial pathogen' named entity 'fever' named entity 'statistical difference' named entity 'etiology' named entity 'Adeno' named entity 'staining' named entity 'PJP' named entity 'HIV infection' named entity 'virus' named entity 'gastrointestinal' named entity 'immunosuppression' named entity 'pulse oximetry' named entity 'mycobacterial' named entity 'Pneumonia' named entity 'viral load' named entity 'lower respiratory tract' named entity 'mortality risk' named entity 'infection' named entity 'HIV infection' named entity 'intensive care unit' named entity 'HIV' named entity 'antigen test' named entity 'respiratory infection' named entity 'ICU'

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