About: Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways

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About: Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
Creator	Jiang, Shibo Li, Xin Shen, Hong Zhang, Qingling Hou, Jinlin He, Li Che, Xiaoyan Ding, Yanqing Cai, Junjie Geng, Jian Han, Huixia Kang, Wei Li, Zhuguo Wang, Huijun Weng, Desheng Huang, Zhongxi Liang, Ping Qiu, Liwen
Source	Medline; PMC
abstract	We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and in situ hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
has issue date	2004-05-07(xsd:dateTime)
bibo:doi	10.1002/path.1560
bibo:pmid	15141376
has license	no-cc
sha1sum (hex)	2080ffcb18a1759661f657c5ebbb9a7c217f6d9f
schema:url	https://doi.org/10.1002/path.1560
resource representing a document's title	Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
has PubMed Central identifier	PMC7167761
has PubMed identifier	15141376
schema:publication	J Pathol
resource representing a document's body	covid:2080ffcb18a1759661f657c5ebbb9a7c217f6d9f#body_text
is schema:about of	named entity 'TRACHEA' named entity 'SYSTEMIC' named entity 'ROUTE' named entity 'GASTROINTESTINAL TRACT' named entity 'ORGAN' named entity 'STUDY' named entity 'UTERUS' named entity 'INFORMATION' named entity 'SUGGEST' named entity 'CAUSED' named entity 'NOT DETECTED' named entity 'CEREBELLUM' named entity 'PATHWAYS' named entity 'THYROID' named entity 'PITUITARY' named entity 'PRESENT' named entity 'MEDIATED' named entity 'PREVIOUSLY' named entity 'infection' named entity 'urine' named entity 'cytopathic effect' named entity 'pituitary' named entity 'SARS' named entity 'muscle' named entity 'testis' named entity 'SARS-CoV' named entity 'severe acute respiratory syndrome' named entity 'intestinal tract' named entity 'distal' named entity 'SARS-CoV' named entity 'SARS-associated coronavirus' named entity 'severe acute respiratory syndrome' named entity 'Wuhan' named entity 'gene' named entity 'virus' named entity 'protein' named entity 'toxic reaction' named entity 'pathogenesis' named entity 'nucleocapsid' named entity 'ovary' named entity 'binding affinity' named entity 'goat' named entity 'antigen' named entity 'pituitary' named entity 'adrenal gland' named entity 'tissue sections' named entity 'SARS' named entity 'thyroid' named entity 'CD13' named entity 'route of transmission' named entity 'pneumocytes' named entity 'SARS-CoV' named entity 'Endogenous' named entity 'ISH' named entity 'nucleocapsid' named entity 'oligonucleotides' named entity 'hydrogen peroxide' named entity 'gene' named entity 'doxycycline' named entity 'formaldehyde' named entity 'blood donors' named entity 'testis' named entity 'lung' named entity 'protein'

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