About: A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure

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About: A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure
Creator	Zhang, Yi Bao, Penghui Jiang, Yan-Fei Wu, Qi-Jia Xie, Mao-Hua
Source	Elsevier; Medline; PMC
abstract	Abstract Recent studies suggest that some RNA-binding proteins facilitate the folding of non-cognate RNAs. Here, we report that bacteriophage MS2 coat protein (MS2 CP) bound and promoted the catalytic activity of Candida group I ribozyme. Cloning of the MS2-bound RNA segments showed that this protein primarily interacts with the P5ab–P5 structure. Ultraviolet cross-linking and the T1 footprinting assay further showed that MS2 binding stabilized tertiary interactions, including the conserved L9–P5 interaction, and led to a more compact core structure. This mechanism is similar to that of the yeast mitochondrial tyrosyl-tRNA synthetase on other group I introns, suggesting that different RNA-binding proteins may use common mechanisms to support RNA structures.
has issue date	2009-01-09(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2008.10.160
bibo:pmid	19000653
has license	els-covid
sha1sum (hex)	209e2dc22ce8aa34dca1bf2101ba64a8a8d922ec
schema:url	https://doi.org/10.1016/j.bbrc.2008.10.160
resource representing a document's title	A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure
has PubMed Central identifier	PMC7117394
has PubMed identifier	19000653
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:209e2dc22ce8aa34dca1bf2101ba64a8a8d922ec#body_text
is schema:about of	named entity 'STRUCTURED' named entity 'cross-linking' named entity 'MS2' named entity 'interaction' named entity 'structure' named entity 'led' named entity 'RNA-binding protein' named entity 'NON-' named entity 'BINDING PROTEIN' named entity 'BACTERIOPHAGE' named entity 'RNA-BINDING PROTEINS' named entity 'COAT PROTEIN' named entity 'RNA' named entity 'CONSERVED' named entity 'LED' named entity 'MS2' named entity 'INTRONS' named entity 'STRUCTURE' named entity 'CLONING' named entity 'BINDS' named entity 'CORE' covid:arg/209e2dc22ce8aa34dca1bf2101ba64a8a8d922ec named entity 'INTERACTION' named entity 'CATALYTIC ACTIVITY' named entity 'HERE' named entity 'BOUND' named entity 'PROTEIN ' named entity 'SUGGEST' named entity 'CORE' named entity 'RNA' named entity 'STABILIZES' named entity 'PHAGE' named entity 'STUDIES' named entity 'TERTIARY' named entity 'MECHANISMS' named entity 'BINDING' named entity 'NON-' named entity 'FOLDING' named entity 'SIMILAR' named entity 'YEAST' named entity 'ITS' named entity 'PROTEIN ' named entity 'COMPACT' named entity 'STRUCTURE' named entity 'COMMON' named entity 'INCLUDING' named entity 'OTHER GROUP' named entity 'GROUP I' named entity 'MITOCHONDRIAL' named entity 'RNAS' named entity 'CANDIDA' named entity 'USE' named entity 'TYROSYL-TRNA SYNTHETASE' named entity 'INTERACTIONS' named entity 'RECENT' named entity 'MECHANISM' named entity 'TO SUPPORT' named entity 'STABILIZED' named entity 'SEGMENTS' named entity 'STRUCTURES' named entity 'DIFFERENT' named entity 'GROUP I RIBOZYME' named entity 'ULTRAVIOLET CROSS-LINKING' named entity 'REPORT' named entity 'FOOTPRINTING ASSAY' named entity 'bound' named entity 'bacteriophage MS2' named entity 'folding' named entity 'segments' named entity 'coat protein' named entity 'cognate' named entity 'ribozyme' named entity 'yeast mitochondrial' named entity 'MS2' named entity 'RNA-binding protein' named entity 'structures' named entity 'Candida'

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