About: Situación actual en el desarrollo de una vacuna preventiva frente al VIH

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About: Situación actual en el desarrollo de una vacuna preventiva frente al VIH Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Situación actual en el desarrollo de una vacuna preventiva frente al VIH
Creator	Esteban, Mariano Alcamí, José Munné, Joan Alcamí, J Madrid, Autónoma
Source	Elsevier; Medline; PMC
abstract	El avance de la epidemia de sida ha convertido la obtención de una vacuna eficaz frente al virus de la inmunodeficiencia humana (VIH) como un objetivo científico prioritario. En el momento actual no disponemos de una vacuna preventiva frente a la infección por el VIH y en ningún modelo animal se ha conseguido la protección frente a la infección. En esta revisión se analizan las dificultades existentes en el desarrollo de una vacuna contra el sida, en especial los mecanismos de escape viral a la respuesta inmunitaria y se describen los prototipos de vacunas preventivas y terapéuticas en desarrollo y los resultados obtenidos. Por otra parte se sitúa esta investigación en el contexto sanitario, económico y social de la pandemia de sida y se analizan las polémicas actualmente planteadas en el desarrollo de ensayos clínicos con los diferentes tipos de vacunas. Due to the uncontrolled progression of the aids epidemic the development of an HIV vaccine has become a major objective of scientific research. An effective preventive vaccine against human immunodeficiency virus (HIV) is not available and sterilising immunity has not yet been achieved in animal models. In this review major challenges in developing an aids vaccine, in particular the mechanisms involved in viral escape to the immune response are analysed, and results obtained with the different prototypes of therapeutic and preventive vaccines summarized. Finally, social, economic and health aspects related to research on HIV vaccines and present controversies regarding the development of clinical trials are discussed.
has issue date	2005-07-31(xsd:dateTime)
bibo:doi	10.1016/s0213-005x(05)75156-9
bibo:pmid	16373000
has license	els-covid
sha1sum (hex)	20b4e39c8395390c96761c787cc204bbec0e7573
schema:url	https://doi.org/10.1016/s0213-005x%2805%2975156-9
resource representing a document's title	Situación actual en el desarrollo de una vacuna preventiva frente al VIH
has PubMed Central identifier	PMC7130300
has PubMed identifier	16373000
schema:publication	Enfermedades Infecciosas y Microbiología Clínica
resource representing a document's body	covid:20b4e39c8395390c96761c787cc204bbec0e7573#body_text
is schema:about of	named entity '2005' named entity 'VIH' named entity 'ACTUAL' named entity 'UNA' named entity 'ALCAM' named entity 'CLIN' named entity '3A5' named entity 'vacuna' named entity 'HLA' named entity 'mismo' named entity 'vacuna' named entity 'HIV vaccine' named entity 'epidemia' named entity 'la segunda' named entity 'convivir' named entity 'CD8' named entity 'retrovirus' named entity 'viremia' named entity 'vacuna' named entity 'los órganos' named entity 'adaptación' named entity 'el momento' named entity 'vacuna' named entity 'Vaccinia' named entity 'la respuesta' named entity 'vacuna' named entity 'gp120' named entity 'búsqueda' named entity 'vacuna' named entity 'simula' named entity 'la respuesta' named entity 'vacuna' named entity 'vacuna' named entity 'vacuna' named entity 'la respuesta' named entity 'el momento' named entity 'vacuna' named entity 'vacuna' named entity 'Estos' named entity 'vacuna' named entity 'igual' named entity 'prevé' named entity 'vacuna' named entity 'esta' named entity 'gp160' named entity 'epidemia' named entity 'por vida' named entity 'la respuesta' named entity 'imposible' named entity 'CD8' named entity 'poliovirus' named entity 'la respuesta' named entity 'HLA' named entity 'la respuesta' named entity 'mismo' named entity 'vacuna' named entity 'vacuna' named entity 'CD4' named entity 'el sistema' named entity 'el mundo' named entity 'vacuna' named entity 'el mundo' named entity 'poliovirus' named entity 'como' named entity 'epidemia' named entity 'vacuna' named entity 'hace' named entity 'el momento' named entity 'mento' named entity 'epidemia' named entity 'clave' named entity 'vacuna' named entity 'más adelante' named entity 'la respuesta' named entity 'epidemia' named entity 'el momento' named entity 'HIV'

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