About: Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption
Creator	Aguiar, Laura Bicho, Manuel De Oliveira, Marcos Do Céu Costa, Maria Gil, Ângela Gorjão-Clara, J Matos, Andreia Pereira Da Silva, Alda Polónia, Jorge
Source	Medline; PMC
abstract	BACKGROUND: Cardiovascular risk (CVR) underlies aging process and longevity. Previous work points to genetic and environmental factors associated with this risk. OBJECTIVES: The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity. METHODS: A case-control study involving 521 both gender individuals, 253 centenarians (100.26 ± 1.98 years), and 268 controls (67.51 ± 3.25 years), low (LCR, n = 107) and high (HCR, n = 161) CVR. Hypertension, diabetes, obesity (BMI, kg·m(−2)), and impaired kidney function were defined according to standard criteria. CVR was calculated using Q risk®. DNA was genotyping (ACE-rs4646994, AGT-rs4762, AGR1-rs5182, GRK4-rs2960306, GRK4-rs1024323, NOS3-rs1799983, and SLC12A3-rs13306673) through iPlex-MassARRAY®, read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE®. RESULTS: Antilongevity factors consisted (OR 95% CI, p < 0.05) BMI 1.558 (1.445-1.680), hypertension 2.358 (1.565-3.553), smoking habits 4.528 (2.579-7.949), diabetes 5.553 (2.889-10.675), hypercholesterolemia 1.016 (1.010-1.022), and regular consumption of red meat 22.363 (13.987-35.755). Genetic aspects particularly for HCR individuals ACE II (OR: 3.96 (1.83-8.56), p < 0.0001) and NOS3 TT (OR: 3.11 (1.70-5.70), p < 0.0001) genotypes were also risk associate. Obesity, smoking, hypercholesterolemia, and frequent consumption of red meat have an additive action to hypertension in the longevity process. There was a synergistic interaction between the endothelial NOS3 genotypes and the severity of arterial hypertension. An epistatic interaction between functional genetic variants of GRK4 and angiotensinogen was also observed. CONCLUSIONS: Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians. Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1155/2020/1305413
bibo:pmid	32714484
has license	cc-by
sha1sum (hex)	20ca6e7a1410504b3aadb5447ee52cd5ccc47c50
schema:url	https://doi.org/10.1155/2020/1305413
resource representing a document's title	Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption
has PubMed Central identifier	PMC7354649
has PubMed identifier	32714484
schema:publication	Oxid Med Cell Longev
resource representing a document's body	covid:20ca6e7a1410504b3aadb5447ee52cd5ccc47c50#body_text
is schema:about of	named entity 'REGULATORS' named entity 'aging process' named entity 'GRK4' named entity 'gene' named entity 'cardiovascular' named entity 'NOS3' named entity 'BMI' named entity 'red meat' named entity 'GRK4' named entity '3.11' named entity 'diabetes' named entity 'SLC12A3' named entity 'environmental factors' named entity 'obesity' named entity 'NOS3' named entity 'BMI' named entity 'endothelial' named entity 'Cardiovascular risk' named entity 'synergistic interaction' named entity 'cholesteryl esters' named entity 'seryl' named entity 'lipid oxidation' named entity 'genetic factors' named entity 'interact' named entity 'AGT' named entity 'environmental factors' named entity 'hypertension' named entity 'atrial fibrillation' named entity 'centenarian' named entity 'normotensive' named entity 'genotype' named entity 'red meat' named entity 'phosphorylation' named entity 'pregnancy' named entity 'risk factor' named entity 'smooth muscle' named entity 'interact' named entity 'enzyme' named entity 'arteries' named entity 'logistic regression' named entity 'WHO' named entity 'Centenarians' named entity 'nitrosylation' named entity 'AGT' named entity 'blood pressure' named entity 'red meat' named entity 'iron' named entity 'control group' named entity 'HDL-c' named entity 'pathologies' named entity 'genotypes' named entity 'aging process' named entity 'EVA' named entity 'high-risk' named entity 'genotypes' named entity 'dependent variable' named entity 'genetic factors' named entity 'oxidant stress' named entity 'allele' named entity 'environmental factors' named entity 'vasodilation' named entity 'cardiovascular' named entity 'algorithm' named entity 'obesity' named entity 'gene' named entity '25.0' named entity 'genetic variants' named entity 'SUPERNOVA' named entity 'polymorphism' named entity 'hypercholesterolemia' named entity 'hypertension' named entity 'polymorphisms' named entity 'genotypic'

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