About: Characterization of MDCK cells and evaluation of their ability to respond to infectious and non-infectious stressors

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About: Characterization of MDCK cells and evaluation of their ability to respond to infectious and non-infectious stressors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of MDCK cells and evaluation of their ability to respond to infectious and non-infectious stressors
Creator	Barbara, Vivaldi Capellini, Francesca Erica, Parisi Ferrari, Giulia, Mignone Lucia, Masiello Massimo, Amadori Razzuoli, Walter, Vencia
source	PMC
abstract	The Madin-Darby Canine Kidney (MDCK) cell line is widely used as epithelial cell model in studies ranging from viral infection to environmental pollutants, and vaccines production. However, little is known about basal expression of genes involved in innate immunity, and the ability to respond to infectious and non-infectious stressors. Therefore, the aims of our study were to evaluate the basal level of expression of pivotal genes in the innate immune response and cell cycle regulation, as well as to evaluate the ability of this cell line to respond to infectious or non-infectious stressors. As surmised in our working hypothesis, we demonstrated the constitutive expression of genes involved in the innate immune response and cell defense alike, including TLRs, Interleukins, Myd88, p65/NF-kB and p53. Moreover, we described the ability of this cell line to respond to LPS and cadmium (Cd2+) in terms of gene expression and cytokine release. These data confirm the possibility of using this cell line as a model in studies of host/pathogen interaction and response to non-infectious stressors.
has issue date	2019-12-04(xsd:dateTime)
bibo:doi	10.1007/s10616-019-00360-z
bibo:pmid	31802289
has license	no-cc
sha1sum (hex)	20da80498694418a62e554b2058abf98fecd4027
schema:url	https://doi.org/10.1007/s10616-019-00360-z
resource representing a document's title	Characterization of MDCK cells and evaluation of their ability to respond to infectious and non-infectious stressors
has PubMed Central identifier	PMC7002637
has PubMed identifier	31802289
schema:publication	Cytotechnology
resource representing a document's body	covid:20da80498694418a62e554b2058abf98fecd4027#body_text
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