About: Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

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About: Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property
Creator	Hilgenfeld, Rolf Hansen, Guido Piotrowski, Yvonne Gorbalenya, Alexander Snijder, Eric Linda Boomaars-Van Der Zanden, A
Source	Medline; PMC
abstract	The polyproteins of coronaviruses are cleaved by viral proteases into at least 15 nonstructural proteins (Nsps). Consisting of five domains, Nsp3 is the largest of these (180–210 kDa). Among these domains, the so-called X-domain is believed to act as ADP-ribose-1″-phosphate phosphatase or to bind poly(ADP-ribose). However, here we show that the X-domain of Infectious Bronchitis Virus (strain Beaudette), a Group-3 coronavirus, fails to bind ADP-ribose. This is explained on the basis of the crystal structure of the protein, determined at two different pH values. For comparison, we also describe the crystal structure of the homologous X-domain from Human Coronavirus 229E, a Group-1 coronavirus, which does bind ADP-ribose.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1002/pro.15
bibo:pmid	19177346
has license	bronze-oa
sha1sum (hex)	210a190d015bd1886f9add90f8570751f41efb26
schema:url	https://doi.org/10.1002/pro.15
resource representing a document's title	Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property
has PubMed Central identifier	PMC2708038
has PubMed identifier	19177346
schema:publication	Protein Science
resource representing a document's body	covid:210a190d015bd1886f9add90f8570751f41efb26#body_text
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