About: Surfactant replacement therapy: from biological basis to current clinical practice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Surfactant replacement therapy: from biological basis to current clinical practice
Creator	Bohlin, Kajsa Danhaive, Olivier Fuchs, Hans Hentschel, Roland Van Kaam, Anton
source	PMC
abstract	This review summarizes the current knowledge on the physiological action of endogenous and exogenous pulmonary surfactant, the role of different types of animal-derived and synthetic surfactants for RDS therapy, different modes of administration, potential risks and strategies of ventilation, and highlights the most promising aims for future development. Scientists have clarified the physicochemical properties and functions of the different components of surfactant, and part of this successful research is derived from the characterization of genetic diseases affecting surfactant composition or function. Knowledge from functional tests of surfactant action, its immunochemistry, kinetics and homeostasis are important also for improving therapy with animal-derived surfactant preparations and for the development of modified surfactants. In the past decade newly designed artificial surfactants and additives have gained much attention and have proven different advantages, but their particular role still has to be defined. For clinical practice, alternative administration techniques as well as postsurfactant ventilation modes, taking into account alterations in lung mechanics after surfactant placement, may be important in optimizing the potential of this most important drug in neonatology.
has issue date	2020-01-11(xsd:dateTime)
bibo:doi	10.1038/s41390-020-0750-8
bibo:pmid	31926483
has license	no-cc
sha1sum (hex)	21a551af356295ada6e657054646444bca9d202b
schema:url	https://doi.org/10.1038/s41390-020-0750-8
resource representing a document's title	Surfactant replacement therapy: from biological basis to current clinical practice
has PubMed Central identifier	PMC7223236
has PubMed identifier	31926483
schema:publication	Pediatr Res
resource representing a document's body	covid:21a551af356295ada6e657054646444bca9d202b#body_text
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