About: Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head
Creator	Fu, Weimin Liu, Baoyi Wang, Benjie Zhao, Dewei
Source	PMC
abstract	OBJECTIVE: This study aims to investigate the early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head. PATIENTS AND METHODS: From January 2010 to January 2014, a total of 350 patients, who required the use of large amounts of hormones, were enrolled into the study. These patients were followed up every three months after starting the hormone therapy. A total of 62 cases were screened, among which nine cases were asymptomatic. Furthermore, 38 patients were diagnosed as stage I and were given low-molecular weight heparin (LMWH) and vasodilator drugs. Moreover, 22 cases were diagnosed as stage IIa/b and underwent core decompression. In addition, two cases were diagnosed as stage IIc and underwent pedicled bone transplantation. During the follow-up period, ARCO staging was used for radiological evaluation, the HHS score was applied to evaluate for clinical efficacy, and SPSS 22.0 statistical software was used for the data analysis. RESULTS: A total of 60 patients were followed up for 24 months. Among these patients, 38 patients were diagnosed with ARCO stage I and underwent systematic therapy. No progress was found in 29 cases (76.3%). Furthermore, three cases progressed to stage IIb (7.8%), four cases progressed to stage IIc (10.5%), two cases progressed to stage III and IV, respectively (2.6%), and 16 cases (80%) did not progress after core decompression. In the 16 cases at stage IIa and four cases at stage IIb, and four cases (20%) progressed in stage III. The HHS score of stage I was 80.42 ± 3.25 before follow-up, while the HHS score was 86.46 ± 8.54 after follow-up, and the difference was statistically significant (P < 0.05). Furthermore, the HHS score of patients with stage IIa/b was 70.38 ± 4.62 before follow-up, while the HHS score was 80.28 ± 6.72 after follow-up, and the difference was statistically significant (P < 0.01). CONCLUSION: MRI remains as the most effective method for the non-invasive diagnosis of osteonecrosis, at present. Enhanced MRI may be able to detect early osteonecrosis, but further research is needed. Drug treatment and core decompression can achieve satisfactory results at the early stage.
has issue date	2018-06-06(xsd:dateTime)
bibo:doi	10.1007/s00264-018-4011-y
bibo:pmid	29876626
has license	no-cc
sha1sum (hex)	21ef02ca4f5f19109724ed482d96fae7ab252845
schema:url	https://doi.org/10.1007/s00264-018-4011-y
resource representing a document's title	Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head
has PubMed Central identifier	PMC7079928
has PubMed identifier	29876626
schema:publication	Int Orthop
resource representing a document's body	covid:21ef02ca4f5f19109724ed482d96fae7ab252845#body_text
is schema:about of	named entity 'diagnosis' named entity 'HHS' named entity 'stage' named entity 'study' named entity 'IIb' named entity 'score' named entity 'addition' named entity 'progressed' named entity 'diagnosis' named entity 'osteonecrosis' named entity 'EVALUATE' named entity 'STAGE IIA' named entity 'FOLLOWED' named entity 'DID' named entity 'BUT' named entity 'REMAINS' named entity 'EARLY' named entity 'PATIENTS' named entity 'PRESENT' named entity '287' named entity 'DRUG TREATMENT' named entity 'LOW' named entity 'therapy' named entity 'IIa' named entity 'osteonecrosis' named entity 'patients' named entity 'cases' named entity '2014' named entity 'January 2010' named entity 'cases' named entity 'IIc' named entity 'early' named entity 'SPSS' named entity 'large' named entity 'cases' named entity 'statistically significant' named entity 'low-molecular weight heparin' named entity 'MRI' named entity 'osteonecrosis' named entity 'statistically significant' named entity '20%' named entity 'hormone therapy' named entity 'SPSS' named entity 'core decompression' named entity 'follow-up' named entity 'follow-up' named entity 'femoral head' named entity 'vasodilator' named entity 'non-invasive' named entity 'score' named entity 'femoral head' named entity 'IIa' named entity 'MRI' named entity 'femoral head' named entity 'femoral head' named entity 'Hormonal' named entity 'core decompression' named entity 'high-risk' named entity 'clinical symptoms' named entity 'cell death' named entity 'femoral head' named entity 'quality of life' named entity 'MRI' named entity 'artificial joint replacement' named entity 'osteonecrosis' named entity 'orthopedics' named entity 'core decompression' named entity 'osteonecrosis' named entity 'crescent sign' named entity 'glucocorticoids' named entity 'long-term' named entity 'corticosteroids' named entity 'osteonecrosis' named entity 'femoral head' named entity 'clinical symptoms' named entity 'ischaemia' named entity 'total hip arthroplasty' named entity 'SPSS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software