About: Potential Immunoregulatory and Antiviral/SARS-CoV-2 Activities of Nitric Oxide

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential Immunoregulatory and Antiviral/SARS-CoV-2 Activities of Nitric Oxide
Creator	Abcdef, Abcdef, George Esch, Tobias Kream, Richard Stefano, George
Source	Medline; PMC
abstract	Nitric oxide (NO) represents a key signaling molecule in multiple regulatory pathways underlying vascular, metabolic, immune, and neurological function across animal phyla. Our brief critical discussion is focused on the multiple roles of the NO signaling pathways in the maintenance of basal physiological states of readiness in diverse cell types mediating innate immunological functions and in the facilitation of proinflammatory-mediated adaptive immunological responses associated with viral infections. Prior studies have reinforced the critical importance of constitutive NO signaling pathways in the homeostatic maintenance of the vascular endothelium, and state-dependent changes in innate immunological responses have been associated with a functional override of NO-mediated inhibitory tone. Accordingly, convergent lines of evidence suggest that dysregulation of NO signaling pathways, as well as canonical oxidative effects of inducible NO, may provide a permissive cellular environment for viral entry and replication. In immunologically compromised individuals, functional override and chronic rundown of inhibitory NO signaling systems promote aberrant expression of unregulated proinflammatory pathways resulting in widespread metabolic insufficiencies and structural damage to autonomous cellular and organ structures. We contend that restoration of normative NO tone via combined pharmaceutical, dietary, or complex behavioral interventions may partially reverse deleterious physiological conditions brought about by viral infection linked to unregulated adaptive immune responses.
has issue date	2020-05-26(xsd:dateTime)
bibo:doi	10.12659/msm.925679
bibo:pmid	32454510
has license	cc-by-nc-nd
sha1sum (hex)	22085b2104670f1f6ab59352501a7ecf141af3ec
schema:url	https://doi.org/10.12659/msm.925679
resource representing a document's title	Potential Immunoregulatory and Antiviral/SARS-CoV-2 Activities of Nitric Oxide
has PubMed Central identifier	PMC7271680
has PubMed identifier	32454510
schema:publication	Med Sci Monit
resource representing a document's body	covid:22085b2104670f1f6ab59352501a7ecf141af3ec#body_text
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