About: Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease

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About: Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease
Creator	Wang, Wei Liu, Xu Zhang, Haibo Chen, Yiwei Chen, Maolin Hao, Zedong Yu, Xindi
Source	PMC
abstract	BACKGROUND: The aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD). METHODS: We performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children’s Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0–1 months old), infants (1–12 months old) and children (1–10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed. RESULTS: A total of 11,651 subjects were included in the study. The overall nosocomial infection rate was 10.8%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 32.9, 15.4, and 5.2%, respectively. Multivariate logistic regression analysis found age (OR 0798, 95%CI: 0.769–0.829; P < 0.001), STS risk grade (OR 1.267, 95%CI: 1.159–1.385; P < 0.001), body mass index (BMI) <5th percentile (OR 1.295, 95%CI: 1.023–1.639; P = 0.032), BMI >95th percentile (OR 0.792, 95%CI: 0.647–0.969; P = 0.023), cardiopulmonary bypass (CPB) time (OR 1.008, 95%CI: 1.003–1.012; P < 0.001) and aortic clamping time (OR 1.009, 1.002–1.015; P = 0.008) were significantly associated with nosocomial infection in CHD infants. After adjusted for confounding factors, we found STS risk grade (OR 1.38, 95%CI: 1.167–1.633; P < 0.001), BMI < 5th percentile (OR 1.934, 95%CI: 1.377–2.715; P < 0.001), CPB time (OR 1.018, 95%CI: 1.015–1.022; P < 0.001), lymphocyte/WBC ratio<cut off value (OR 3.818, 95%CI: 1.529–9.533; P = 0.004) and AST>cut off value (OR 1.546, 95%CI: 1.119–2.136; P = 0.008) were significantly associated with nosocomial infection in CHD children. CONCLUSION: Our study suggested STS risk grade, BMI, CPB duration, low lymphocyte/WBC or high neutrophil/WBC ratio were independently associated with nosocomial infection in CHD infant and children after cardiac surgery.
has issue date	2020-01-21(xsd:dateTime)
bibo:doi	10.1186/s12879-020-4769-6
bibo:pmid	31964345
has license	cc-by
sha1sum (hex)	2221ce7b64ba6ab8643f0bbec678b9a23302a42c
schema:url	https://doi.org/10.1186/s12879-020-4769-6
resource representing a document's title	Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease
has PubMed Central identifier	PMC6975050
has PubMed identifier	31964345
schema:publication	BMC Infect Dis
resource representing a document's body	covid:2221ce7b64ba6ab8643f0bbec678b9a23302a42c#body_text
is schema:about of	named entity 'infants' named entity 'cardiac surgery' named entity 'PATIENTS' named entity 'AIM' named entity 'ASSOCIATION' named entity 'CHILDREN' covid:arg/2221ce7b64ba6ab8643f0bbec678b9a23302a42c named entity 'nosocomial infection' named entity 'Shanghai' named entity 'Children' named entity 'congenital heart disease' named entity 'CHD' named entity 'Risk factors' named entity 'probability' named entity 'congenital malformations' named entity 'cardiac surgery' named entity 'Nosocomial infection' named entity 'biomarkers' named entity 'congenital heart disease' named entity 'risk factors' named entity 'congenital heart disease' named entity 'infection' named entity 'Neutrophils' named entity 'higher risk' named entity 'Congenital heart disease' named entity 'risk factors' named entity 'nomograms' named entity 'area under the curve' named entity 'heart surgery' named entity 'cross validation' named entity 'hospital infections' named entity 'nosocomial infection' named entity 'neutrophil' named entity 'ICU' named entity 'WBC' named entity 'cross validation' named entity 'nosocomial infection' named entity 'cardiac surgery' named entity 'ventilator support' named entity 'nomograms' named entity 'BMI' named entity 'case study' named entity 'laboratory test' named entity 'cardiac surgery' named entity 'China' named entity 'BMI' named entity 'neonatal' named entity 'multivariate analysis' named entity 'lymphocyte' named entity 'inflammatory mediators' named entity 'cardiac surgery' named entity 'cardiac surgery' named entity 'discrimination' named entity 'BMI' named entity 'BMI' named entity 'nosocomial infection' named entity 'Aortic cross-clamp' named entity 'surgical site infections' named entity 'mechanical ventilation' named entity 'cardiac surgery' named entity 'pediatric' named entity 'ventilator' named entity 'post-operative' named entity 'Demographic characteristics' named entity 'cardiac surgery' named entity 'area under the curve' named entity 'congenital heart disease' named entity 'risk factors' named entity 'cardiac surgery' named entity 'nosocomial infection' named entity 'nosocomial infection' named entity 'number of new cases' named entity 'WBC' named entity 'ICU' named entity 'WBC'

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