About: Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis

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About: Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis
Creator	Melamed, Sharon Paran, Nir Futerman, Anthony Klausner, Ziv Avraham, Roy Erez, Noam Israely, Tomer Vitner, Einat Rothbard, Deborah
source	Medline; PMC
abstract	Both monogenic diseases and viral infections can manifest in a broad spectrum of clinical phenotypes that range from asymptomatic to lethal, suggesting that other factors modulate disease severity. Here, we examine the interplay between the genetic neuronopathic Gaucher’s disease (nGD), and neuroinvasive Sindbis virus (SVNI) infection. Infection of nGD mice with SVNI had no influence on nGD severity. However, nGD mice were more resistant to SVNI infection. Significantly different inflammatory responses were seen in nGD brains when compared with SVNI brains: the inflammatory response in the nGD brains consisted of reactive astrocytes and microglia with no infiltrating macrophages, but the inflammatory response in the brains of SVNI-infected mice was characterized by infiltration of macrophages and altered activation of microglia and astrocytes. We suggest that the innate immune response activated in nGD confers resistance against viral infection of the CNS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40478-020-01020-6) contains supplementary material, which is available to authorized users.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1186/s40478-020-01020-6
bibo:pmid	32831144
has license	cc-by
sha1sum (hex)	2249a3132959f3aa66291e9417033aacc6f60fdd
schema:url	https://doi.org/10.1186/s40478-020-01020-6
resource representing a document's title	Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis
has PubMed Central identifier	PMC7443817
has PubMed identifier	32831144
schema:publication	Acta Neuropathol Commun
resource representing a document's body	covid:2249a3132959f3aa66291e9417033aacc6f60fdd#body_text
is schema:about of	named entity 'brains' named entity 'fdr' named entity 'monogenic diseases' named entity 'genes' named entity 'range' named entity 'Gene' named entity 'interplay' named entity 'CBE' named entity 'MAPS' named entity 'HERE' named entity 'RESISTANCE' named entity 'PHENOTYPES' named entity 'ACTIVATION' named entity 'ALTERED' named entity 'BUT' named entity 'VALUES' named entity 'GAUCHER' named entity 'DATA' named entity 'innate immune response' named entity 'brains' named entity 'microglia' named entity 'astrocytes' named entity 'genes' named entity 'Infection' named entity 'viral infections' named entity 'brains' named entity 'Gaucher disease' named entity 'CBE' named entity 'infection' named entity 'microglia' named entity 'inflammatory responses' named entity 'neuroinvasive' named entity 'asymptomatic' named entity 'mRNA' named entity 'mice' named entity 'viral infection' named entity 'monogenic diseases' named entity 'expressed genes' named entity 'inflammatory response' named entity '2.0' named entity 'Infection' named entity 'RNAseq' named entity 'Sindbis virus' named entity 'encephalitis' named entity 'epoxide' named entity 'pathogen' named entity 'immunoreactivity' named entity 'CBE' named entity 'CBE' named entity 'CBE' named entity 'virus' named entity 'Neuropathology' named entity 'HPRT' named entity 'M. musculus' named entity 'genetic diseases' named entity 'GFAP' named entity 'interferon' named entity 'C1q' named entity 'CBE' named entity 'Gpr34' named entity 'RNAseq' named entity 'qPCR' named entity 'xylazine' named entity 'immunohistochemistry' named entity 'Zika' named entity 'IBA1' named entity 'down-regulated' named entity 'Kruskal-Wallis test' named entity 'homogenates' named entity 'murine models' named entity 'murine' named entity 'Applied Biosystems' named entity 'CBE'

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