About: Increased replication of respiratory syncytial virus in the presence of cytokeratin 8 and 18

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increased replication of respiratory syncytial virus in the presence of cytokeratin 8 and 18
Creator	Ujike, Makoto Matsuyama, Shutoku Shirato, Kazuya Kawase, Miyuki
source	Medline; PMC
abstract	Previously, it was reported that productive viral infection, viral protein synthesis, and viral RNA replication of respiratory syncytial virus (RSV) operated efficiently in two human epithelial cell lines (HEp‐2 and A549), but not in a human mast‐cell line, HMC‐1. Based on these observations, it was hypothesized that HMC‐1 cells lack the machinery required for RSV replication. To identify the host factors required for RSV replication, cDNA subtraction using A549, HEp‐2, and HMC‐1 cells was performed, and cytokeratin 18 (C18) was identified as a candidate host factor. Because C18 is generally expressed in simple epithelia with cytokeratin 8 (C8), HMC‐1 cells that constitutively express C18 and C8 (HMC‐1‐C8/18) were established to evaluate the role of C8/18 in RSV replication. In HMC‐1‐C8/18 cells, RSV RNA replication was increased, and the amount of infective virus produced was also increased in the cellular fraction after RSV spinoculation, whereas RSV production was decreased in A549 cells in which C18 expression was knocked down. These data suggest that the replication of RSV increases in the presence of C8/18. J. Med. Virol. 84:365–370, 2012. © 2011 Wiley Periodicals, Inc.
has issue date	2011-12-14(xsd:dateTime)
bibo:doi	10.1002/jmv.23196
bibo:pmid	22170560
has license	no-cc
sha1sum (hex)	2260e7bc70dccb0761daf5aa6a7a68059cf694c6
schema:url	https://doi.org/10.1002/jmv.23196
resource representing a document's title	Increased replication of respiratory syncytial virus in the presence of cytokeratin 8 and 18
has PubMed Central identifier	PMC7166714
has PubMed identifier	22170560
schema:publication	J Med Virol
resource representing a document's body	covid:2260e7bc70dccb0761daf5aa6a7a68059cf694c6#body_text
is schema:about of	named entity 'virus' named entity 'machinery' named entity 'C18' named entity 'cellular' named entity 'viral protein' named entity 'RSV' named entity 'constitutively' named entity 'A549' named entity 'HMC' named entity 'HMC' named entity 'human' named entity 'protein synthesis' named entity 'viral' named entity 'human' named entity 'data' named entity 'HMC' named entity 'RSV' named entity 'RSV' named entity 'RNA' named entity 'C18' named entity 'epithelia' named entity 'RSV' named entity 'RSV' named entity 'viral infection' named entity 'RSV' named entity 'RSV' named entity 'virus' named entity 'C18' named entity 'Respiratory Syncytial Virus' named entity 'hypothesized' named entity 'RSV' named entity 'RSV' named entity 'virus' named entity 'adenovirus infection' named entity 'A549' named entity 'protein' named entity 'coronaviruses' named entity 'Cloning' named entity 'sequence homology' named entity 'C18' named entity 'physical interaction' named entity 'HEp-2' named entity 'GenBank' named entity 'knocked-down' named entity 'RSV' named entity 'viruses' named entity 'RNA' named entity 'RNA' named entity 'homolog' named entity 'RSV' named entity 'C18' named entity 'C18' named entity 'real-time PCR' named entity 'A549' named entity 'RSV' named entity 'RSV' named entity 'rRNA' named entity 'mRNA expression' named entity 'titer' named entity 'Becton Dickinson' named entity 'C18' named entity 'plaque assay' named entity 'flow cytometry' named entity 'RSV' named entity 'infection' named entity 'virus' named entity 'RSV' named entity 'type I collagen' named entity 'FITC' named entity 'C18' named entity 'cytokeratins' named entity 'HEp-2' named entity 'viral infection' named entity 'American Academy of Pediatrics' named entity 'C18' named entity 'homologies' named entity 'vimentin' named entity 'A549'

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