About: A canine model of experimental infection with Leishmania (L.) mexicana

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About: A canine model of experimental infection with Leishmania (L.) mexicana Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A canine model of experimental infection with Leishmania (L.) mexicana
Creator	Dumonteil, Eric Estefanía Villanueva-Lizama, Liliana Jesús Ramírez-Sierra, Maria Pablo Martínez-Vega, Pedro Aguilar-Cetina, Carmen Cruz-Chan, Julio Del, Amarú Leonardo, José Rosado-Vallado, Miguel
Source	Medline; PMC
abstract	BACKGROUND: Cutaneous leishmaniasis is a tropical disease affecting over one million patients annually and Leishmania (L.) mexicana is one of the major etiological agents in the Americas. Here we established the first experimental infection of L. (L.) mexicana in canids. METHODS: Beagle dogs were infected intradermally with culture-derived L. (L.) mexicana. We followed skin ulcer development, histopathological signs, parasite burden and the immune status of the infected dogs. RESULTS: All infected dogs developed uniform oval-craterform ulcers similar to those observed in humans, associated with mixed T helper 1/T helper 2 immune responses. Parasites were detected in the healed lesions 15 weeks post-infection. Higher anti-Leishmania IgG levels correlated with larger lesions and high IgG1/IgG2 ratio was associated with some level of splenomegaly. CONCLUSIONS: The canine model described in this work will be of use for further understanding of L. (L.) mexicana immunopathogenensis, and for drug and vaccine development.
has issue date	2014-08-09(xsd:dateTime)
bibo:doi	10.1186/1756-3305-7-361
bibo:pmid	25108307
has license	cc-by
sha1sum (hex)	22d734ce865dda20bbbbd2695ffe67cb5bb10445
schema:url	https://doi.org/10.1186/1756-3305-7-361
resource representing a document's title	A canine model of experimental infection with Leishmania (L.) mexicana
has PubMed Central identifier	PMC4138396
has PubMed identifier	25108307
schema:publication	Parasit Vectors
resource representing a document's body	covid:22d734ce865dda20bbbbd2695ffe67cb5bb10445#body_text
is schema:about of	named entity 'mexicana' named entity 'skin ulcer' named entity 'disease' named entity 'mexicana' named entity 'Cutaneous leishmaniasis' named entity 'HERE' named entity 'DERIVED' named entity 'FOLLOWED' named entity 'HISTOPATHOLOGICAL' named entity 'PARASITE' named entity 'MEXICANA' named entity 'EXPERIMENTAL INFECTION' named entity 'BACKGROUND' named entity 'IMMUNE STATUS' named entity 'SIGNS' named entity 'TROPICAL DISEASE' named entity 'LEISHMANIA' named entity 'INFECTED' named entity 'LEISHMANIA' named entity 'CANIDS' named entity 'PATIENTS' named entity 'SKIN ULCER' named entity 'ANNUALLY' named entity 'ESTABLISHED' named entity 'MAJOR' named entity 'BURDEN' named entity 'ONE MILLION' named entity 'DEVELOPMENT' named entity 'MEXICANA' named entity 'DOGS' named entity 'EXPERIMENTAL INFECTION' named entity 'BEAGLE' named entity 'ONE OF' named entity 'CUTANEOUS LEISHMANIASIS' named entity 'CULTURE' named entity 'AMERICAS' named entity 'METHODS' named entity 'IS A' named entity 'CANINE' named entity 'MODEL OF' named entity 'AFFECTING' covid:arg/22d734ce865dda20bbbbd2695ffe67cb5bb10445 named entity 'dogs' named entity 'development' named entity 'immune status' named entity 'Cutaneous leishmaniasis' named entity 'Beagle dogs' named entity 'tropical disease' named entity 'Americas' named entity 'histopathological' named entity 'goat' named entity 'parasites' named entity 'hematoxylin and eosin' named entity 'saliva' named entity 'lesion' named entity 'cutaneous leishmaniasis' named entity 'infection' named entity 'cutaneous leishmaniasis' named entity 'visceral leishmaniasis' named entity 'serum' named entity 'parasites' named entity 'spleen' named entity 'St. Louis' named entity 'cytokine' named entity 'IgG' named entity 'sonicated' named entity 'promastigotes' named entity 'IL-10' named entity 'experimental models' named entity 'canine' named entity 'chronic inflammation' named entity 'dermis' named entity 'liver'

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