About: The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

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About: The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection
Creator	Ding, Chan Yu, Shengqing Hu, Hai Tian, Mingxing De Bernard, Marina Kruyt, Frank Robson, Matthew
Source	PMC
abstract	Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal environment. Apoptosis is an initiative cell death process that is controlled by genes and is mainly divided into endogenous pathways (mitochondrial pathway), exogenous pathways (death receptor pathway), and apoptotic pathways induced by endoplasmic reticulum (ER) stress. The homeostasis imbalance in ER results in ER stress. Under specific conditions, ER stress can be beneficial to the body; however, if ER protein homeostasis is not restored, the prolonged activation of the unfolded protein response may initiate apoptotic cell death via the up-regulation of the C/EBP homologous protein (CHOP). CHOP plays an important role in ER stress-induced apoptosis and this review focuses on its multifunctional roles in that process, as well as its role in apoptosis during microbial infection. We summarize the upstream and downstream pathways of CHOP in ER stress induced apoptosis. We also focus on the newest discoveries in the functions of CHOP-induced apoptosis during microbial infection, including DNA and RNA viruses and some species of bacteria. Understanding how CHOP functions during microbial infection will assist with the development of antimicrobial therapies.
has issue date	2019-01-04(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.03083
bibo:pmid	30662442
has license	cc-by
sha1sum (hex)	235fab2608254fb0e97f003cef3b4694bc003756
schema:url	https://doi.org/10.3389/fimmu.2018.03083
resource representing a document's title	The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection
has PubMed Central identifier	PMC6328441
has PubMed identifier	30662442
schema:publication	Front Immunol
resource representing a document's body	covid:235fab2608254fb0e97f003cef3b4694bc003756#body_text
is schema:about of	named entity 'apoptosis' named entity 'Apoptosis' named entity 'bacteria' named entity 'development' named entity 'C/EBP' named entity 'environment' named entity 'C/EBP' named entity 'Protein' named entity 'HOMOLOGOUS PROTEIN' named entity 'FUNCTIONS' named entity 'RECEPTOR' named entity 'REVIEW' named entity 'PLAYS' named entity 'INTERNAL' named entity 'ACTIVATION' named entity 'HOW' named entity 'ASSIST' named entity 'IS A' named entity 'PATHWAY' named entity 'DIVIDED' named entity 'CONDITIONS' named entity 'ANTIMICROBIAL' named entity 'APOPTOSIS' named entity 'SPECIFIC' named entity 'CHOP' named entity 'FOCUS' named entity 'ENDOGENOUS' named entity 'UNDERSTANDING' named entity 'ENDOPLASMIC RETICULUM' named entity 'APOPTOTIC' named entity 'FORM' named entity 'STRESS' named entity 'ITS' named entity 'DOWNSTREAM' named entity 'EXOGENOUS' named entity 'RNA VIRUSES' named entity 'ROLE' named entity 'RESULTS' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PATHWAYS' named entity 'INITIATIVE' named entity 'HOMOLOGOUS PROTEIN' named entity 'THE UP' named entity 'ENVIRONMENT' named entity 'BENEFICIAL' named entity 'FUNCTIONS' named entity 'BODY' named entity 'CONTROLLED BY' named entity 'CELL DEATH' named entity 'TRANSCRIPTION FACTOR' named entity 'MICROBIAL INFECTION' named entity 'INITIATE' named entity 'ENDOPLASMIC RETICULUM STRESS-INDUCED APOPTOSIS' named entity 'INCLUDING' named entity 'UP-REGULATION' named entity 'DNA' named entity 'SPECIES' named entity 'GENES' named entity 'HOMEOSTASIS' named entity 'PROCESS' named entity 'BACTERIA.' named entity 'IMPORTANT' named entity 'ER STRESS-INDUCED APOPTOSIS' named entity 'ER STRESS' named entity 'THERAPIES' named entity 'PROTEIN ' named entity 'MICROBIAL INFECTION' named entity 'PROTEIN ' named entity 'ROLES' named entity 'APOPTOTIC CELL DEATH' named entity 'DEVELOPMENT' named entity 'UPSTREAM' named entity 'PROLONGED' named entity 'HOMEOSTASIS IMBALANCE' named entity 'INDUCED'

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