About: Induction of lactogenic immunity to transmissible gastroneteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Induction of lactogenic immunity to transmissible gastroneteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of lactogenic immunity to transmissible gastroneteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract
Creator	Aynaud, J Bernard, S Bottreau, E Lantier, I Salmon, H Vannier, Ph
Source	Elsevier; Medline; PMC
abstract	Abstract A trasmissible gastroenteritis (TGE) coronavirus mutant (188-SG), selected as attenuated and resistant to acidity and proteases of the digestive tract of adult pigs, was used as vaccine (“Nouzilly strain”) in sows to protect suckling piglets against a challenge exposure carried out with a higly virulent TGEV strain. The pregnant sows were immunized once (42–49 days before farrowing) or twice (42–49 and 7–15 days before farrowing) by the oral, intramuscular or conjunctival route with the 188-SG strain. Sows exposed to virulent TGEV in the field and experimentally infected sows (two oral inoculations during pregnancy) were used as positive controls leading to high protection. The neutralizing antibody response to vaccination and/or infection was studied in serum and milk. No protection against mortality was observed in the litters of (1) the nine seronegative, susceptible sows, with piglet mortality of 65/70, (2) the seven once orally vaccinated sows, with mortality of 44/54, (3) the seven sows vaccinated twice by the conjunctival route, with mortality of 55/76. Moderate protection was observed in (1) the eight sows vaccinated intramuscularly twice with piglet mortality of 36/90, (2) the seven orally and intramuscularly vaccinated sows with piglet mortality of 31/51. In contrast, improved protection was observed in (1) the 10 sows vaccinated twice orally, with piglet mortality of 23/95, (2) the four naturally infected sows with piglet mortality of 6/41, (3) the six sows experimentally infected with virulent TGEV with piglet mortality of 1/59. No correlation was found between neutralizing antibodies titers in serum and milk and protection rate of the piglets. The results indicate that relative protective lactogenic immunity against TGEV is induced only by repeated ingestion of -SG attenuated 188-SG strain of TGEV.
has issue date	1991-02-01(xsd:dateTime)
bibo:doi	10.1016/0378-1135(91)90016-9
bibo:pmid	1850894
has license	els-covid
sha1sum (hex)	23709edad9f21fa94694b86fc97c118f85756155
schema:url	https://doi.org/10.1016/0378-1135%2891%2990016-9
resource representing a document's title	Induction of lactogenic immunity to transmissible gastroneteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract
has PubMed Central identifier	PMC7117156
has PubMed identifier	1850894
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:23709edad9f21fa94694b86fc97c118f85756155#body_text
is schema:about of	named entity 'USING' named entity 'SWINE' named entity 'transmissible' named entity 'immunity' named entity 'coronavirus' named entity 'DIGESTIVE TRACT' named entity 'ATTENUATED' named entity 'IMMUNITY' named entity 'ATTENUATED' named entity '239' named entity 'IMMUNITY' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'ENVIRONMENT' named entity 'DIGESTIVE TRACT' named entity 'USING' named entity 'CORONAVIRUS' named entity 'PHYSICOCHEMICAL' named entity 'CORONAVIRUS' named entity 'SURVIVE' named entity 'ENVIRONMENT' named entity 'INDUCTION' named entity 'MUTANT' named entity 'VET' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'PHYSICOCHEMICAL' named entity 'SWINE' named entity 'SURVIVE' named entity 'MUTANT' named entity 'SALMON' named entity 'INDUCTION' covid:arg/23709edad9f21fa94694b86fc97c118f85756155 named entity 'Salmon' named entity 'coronavirus' named entity 'gastroenteritis' named entity 'lactogenic' named entity 'swine' named entity 'lactogenic' named entity 'milk' named entity 'conjunctival' named entity 'milk' named entity 'vaccines' named entity 'virus' named entity 'antibody' named entity 'serum' named entity '17 months ago' named entity 'neonatal' named entity 'dehydration' named entity 'serum' named entity 'virulent' named entity 'infectivity' named entity 'intramuscular' named entity 'conjunctival' named entity 'inactivated vaccine' named entity 'serum' named entity 'titration' named entity 'milk' named entity 'proteases' named entity 'physico-chemical' named entity 'serum' named entity 'antibody' named entity 'immunization' named entity 'antigen' named entity 'intramuscular' named entity 'antibody response' named entity 'morbidity' named entity 'serum' named entity 'Seronegative' named entity 'immunization' named entity 'vaccination' named entity 'lactogenic' named entity 'milk' named entity 'cell line' named entity 'milk' named entity 'virus' named entity 'oral administration' named entity 'intramuscular'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software