About: Early events during human coronavirus OC43 entry to the cell

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Early events during human coronavirus OC43 entry to the cell
Creator	Milewska, Aleksandra Pyrc, Krzysztof Owczarek, Katarzyna Rajfur, Zenon Baster, Zbigniew Szczepanski, Artur Sarna, Michal
source	Medline; PMC
abstract	The Coronaviridae family clusters a number of large RNA viruses, which share several structural and functional features. However, members of this family recognize different cellular receptors and exploit different entry routes, what affects their species specificity and virulence. The aim of this study was to determine how human coronavirus OC43 enters the susceptible cell. Using confocal microscopy and molecular biology tools we visualized early events during infection. We found that the virus employs caveolin-1 dependent endocytosis for the entry and the scission of virus-containing vesicles from the cell surface is dynamin-dependent. Furthermore, the vesicle internalization process requires actin cytoskeleton rearrangements. With our research we strove to broaden the understanding of the infection process, which in future may be beneficial for the development of a potential therapeutics.
has issue date	2018-05-08(xsd:dateTime)
bibo:doi	10.1038/s41598-018-25640-0
bibo:pmid	29740099
has license	cc-by
sha1sum (hex)	2410516def70473a479454501fab2cdaf95d88d3
schema:url	https://doi.org/10.1038/s41598-018-25640-0
resource representing a document's title	Early events during human coronavirus OC43 entry to the cell
has PubMed Central identifier	PMC5940804
has PubMed identifier	29740099
schema:publication	Sci Rep
resource representing a document's body	covid:2410516def70473a479454501fab2cdaf95d88d3#body_text
is schema:about of	named entity 'virus' named entity 'However' named entity 'determine' named entity 'tools' named entity 'EVENTS' covid:arg/2410516def70473a479454501fab2cdaf95d88d3 named entity 'MEMBERS' named entity 'VIRULENCE' named entity 'CELL SURFACE' named entity 'OUR' named entity 'HOW' named entity 'POTENTIAL' named entity 'VESICLES' named entity 'EARLY' named entity 'THERAPEUTICS' named entity 'CAVEOLIN-1' named entity 'LARGE' named entity 'FUNCTIONAL' named entity 'DETERMINE' named entity 'RESEARCH' named entity 'THEIR' named entity 'EVENTS' named entity 'FEATURES' named entity 'TOOLS' named entity 'SPECIES SPECIFICITY' named entity 'PROCESS' named entity 'CONTAINING' named entity 'ENTRY' named entity 'DEPENDENT' named entity 'VIRUS' named entity 'VISUALIZED' named entity 'BENEFICIAL' named entity 'CORONAVIRIDAE' named entity 'DYNAMIN' named entity 'WHAT' named entity 'USING' named entity 'MOLECULAR BIOLOGY' named entity 'CELLULAR' named entity 'FUTURE' named entity 'VESICLE' named entity 'INTERNALIZATION' named entity 'UNDERSTANDING' named entity 'THE CELL' named entity 'OPEN' named entity 'HUMAN CORONAVIRUS OC43' named entity 'CONFOCAL MICROSCOPY' named entity 'HUMAN CORONAVIRUS OC43' named entity 'ENTRY' named entity 'ROUTES' named entity 'EXPLOIT' named entity 'INFECTION' named entity 'STRUCTURAL' named entity 'SUSCEPTIBLE' named entity 'DIFFERENT' named entity 'EMPLOYS' named entity 'SHARE' named entity 'ENDOCYTOSIS' named entity 'RECOGNIZE' named entity 'FAMILY' named entity 'EARLY' named entity 'RNA VIRUSES' named entity 'AIM' named entity 'ACTIN CYTOSKELETON' named entity 'NUMBER OF' named entity 'MAY BE' named entity 'CLUSTERS' named entity 'INFECTION PROCESS' named entity 'FOUND' named entity 'CELL' named entity 'DEVELOPMENT' named entity 'STUDY' named entity 'RECEPTORS' named entity 'REARRANGEMENTS' named entity 'events' named entity 'OC43'

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