About: MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

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About: MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015
Creator	Peiris, Malik Song, Kyoung-Ho Poon, Leo Peiris, M Kim, Nam-Joong Oh, Myoung-Don Poon, L Bang, Ji Kim, Eu Kim, H Kim, Hong Lau, E Lau, Eric Park, S Park, Sang Park, Wan Bang, J Choe, Kim, E Kim, N.-J Pyoeng, Gyun Choe, P Ko, L Ko, Ronald Park, W Perera, R Song, K.-H Wei, Long
Source	Medline; PMC
abstract	We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.
has issue date	2017-07-01(xsd:dateTime)
bibo:doi	10.3201/eid2307.170310
bibo:pmid	28585916
has license	no-cc
sha1sum (hex)	244a3bd441bc1a9400a8529ed9933ae8a1f8d00a
schema:url	https://doi.org/10.3201/eid2307.170310
resource representing a document's title	MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015
has PubMed Central identifier	PMC5512479
has PubMed identifier	28585916
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:244a3bd441bc1a9400a8529ed9933ae8a1f8d00a#body_text
is schema:about of	named entity 'EID' named entity 'podcasts' named entity 'Unraveling' named entity 'GOV' named entity 'WEBSITE' named entity 'OUR' named entity 'CDC' named entity 'VISIT' named entity 'SOUTH KOREA' named entity '2015' named entity 'YEAR' named entity 'MERS-COV' named entity 'ANTIBODY' named entity 'PODCAST' named entity 'HTTP' named entity 'RESPONSES' named entity 'SYMPTOM ONSET' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'LISTEN' named entity 'ASP' named entity 'Year' named entity 'Antibody' named entity 'Symptom' named entity 'optical density' named entity 'infection' named entity 'infection' named entity 'microneutralization' named entity 'MERS' named entity 'SNU' named entity 'clinical characteristics' named entity 'infection' named entity 'viruses' named entity 'microneutralization' named entity 'viral shedding' named entity 'supplemental oxygen' named entity 'MERS-CoV' named entity 'antibody' named entity 'MERS-CoV' named entity 'outbreak in South Korea' named entity 'spike protein' named entity 'microneutralization' named entity 'virus' named entity 'titer' named entity 'neutralizing antibody' named entity 'nosocomial' named entity 'MERS-CoV' named entity 'acute phase' named entity 'reference range' named entity 'neutralization tests' named entity 'dromedary camels' named entity 'lung' named entity 'titer' named entity 'antibody' named entity 'infection'

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