About: Chapter 11.6 Clays and Clay Minerals as Drugs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chapter 11.6 Clays and Clay Minerals as Drugs
Creator	Droy-Lefaix, M Tateo, And
Source	Elsevier; Medline; PMC
abstract	Publisher Summary This chapter discusses the applications of clays and clay materials as drugs. Clay minerals are efficient against several aggressors that cause major disorders of the gut. These beneficial effects of clay minerals (on the gastrointestinal mucosa) are associated with two mechanisms of action: (1) adsorption of the aggressors or their toxic secretions and (2) modification of the thickness and rheological properties of the adherent mucus, reinforcing the natural defenses of the gastrointestinal mucosa. At the surface of the gut, a mucus gel adheres to the epithelial cells of the mucosa. This adherent mucus is dynamic, being continuously secreted by the calceiform cells and regularly eroded by environmental aggressors present in the gut lumen. The mucus gel is largely composed of glycoprotein polymers, lipids, and proteins linked together by covalent bonds. It acts as a physical barrier protecting the mucosa against penetration by extraneous molecules and mechanical injury. By maintaining a pH gradient and competing with the epithelial surface for microorganisms, the mucus gel also acts as a chemical barrier.
has issue date	2006-12-31(xsd:dateTime)
bibo:doi	10.1016/s1572-4352(05)01025-1
bibo:pmid	32362802
has license	els-covid
sha1sum (hex)	244ca34b4ce1ca259d290c3eed80339ecd0d9c1f
schema:url	https://doi.org/10.1016/s1572-4352%2805%2901025-1
resource representing a document's title	Chapter 11.6 Clays and Clay Minerals as Drugs
has PubMed Central identifier	PMC7185446
has PubMed identifier	32362802
schema:publication	Developments in Clay Science
resource representing a document's body	covid:244ca34b4ce1ca259d290c3eed80339ecd0d9c1f#body_text
is schema:about of	named entity 'CLAYS' named entity 'MINERALS' named entity 'DRUGS' named entity 'CLAY' named entity 'free radicals' named entity 'smectite' named entity 'smectite' named entity 'clay minerals' named entity 'adsorptive' named entity 'infectious agent' named entity 'mucus' named entity 'clay minerals' named entity 'adsorption' named entity 'potential difference' named entity 'adsorbing' named entity 'H. pylori' named entity 'mucosa' named entity 'smectite' named entity 'TNF-a' named entity 'Clay minerals' named entity 'herbicide' named entity 'gastrointestinal' named entity 'polymerization' named entity 'mucus' named entity 'boehmite' named entity 'Guinea pigs' named entity 'clinical data' named entity 'hydrogen' named entity 'Bacteroides fragilis' named entity 'attapulgite' named entity 'urine analysis' named entity 'erosion' named entity 'smectite' named entity 'gastrointestinal' named entity 'adsorptive' named entity 'natural defenses' named entity 'mucosa' named entity 'colonic mucosa' named entity 'Clay minerals' named entity 'Ethanol' named entity 'toxin' named entity 'cow milk' named entity 'clay minerals' named entity 'Vibrio cholerae' named entity 'irritative' named entity 'cholera toxin' named entity 'Clay minerals' named entity 'ulceration' named entity 'adsorbing' named entity 'chemical properties' named entity 'TNF-a' named entity 'mycotoxins' named entity 'enterotoxins' named entity 'faeces' named entity 'Yersinia pseudotuberculosis' named entity 'mucus' named entity 'smectite' named entity 'hypersecretion' named entity 'mucus' named entity 'flatulence' named entity 'smectite' named entity 'hypersecretion' named entity 'digestive diseases' named entity 'mucus layer' named entity 'Food allergy' named entity 'polymerization' named entity 'Clay minerals' named entity 'J.L.' named entity 'mucus' named entity 'HeLa' named entity 'smectite' named entity 'biopsies' named entity 'E. coli' named entity 'reactive oxygen species' named entity 'pH gradient' named entity 'enzyme activity' named entity 'ethanol' named entity 'toxin' named entity 'mucus' named entity 'gastritis'

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