About: Viral infections associated with haemophagocytic syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral infections associated with haemophagocytic syndrome
Creator	Jacob, Jesse Albrecht, Helmut Moanna, Abeer Rouphael Maakaroun, Nadine
Source	Medline; PMC
abstract	Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and NK cells. This T cell/NK cell dysregulation causes an aberrant cytokine release, resulting in proliferation/activation of histiocytes with subsequent haemophagocytosis. Histiocytic infiltration of the reticuloendothelial system results in hepatomegaly, splenomegaly, lymphadenopathy and pancytopenia ultimately leading to multiple organ dysfunctions. Common clinical features include high fevers despite broad spectrum antimicrobials, maculopapular rash, neurological symptoms, coagulopathy and abnormal liver function tests. Haemophagocytic syndrome can be either primary, i.e. due to an underlying genetic defect or secondary, associated with malignancies, autoimmune diseases (also called macrophage activation syndrome) or infections. Infectious triggers are most commonly due to viral infections mainly of the herpes group, with EBV being the most common cause. HPS can be fatal if untreated. Early recognition of the clinical presentation and laboratory abnormalities associated with HPS and prompt initiation of treatment can be life saving. HPS triggered by viral infections generally does not respond to specific antiviral therapy but may be treated with immunosuppressive/immunomodulatory agents and, in refractory cases, with bone marrow transplantation. Copyright © 2010 John Wiley & Sons, Ltd.
has issue date	2010-02-01(xsd:dateTime)
bibo:doi	10.1002/rmv.638
bibo:pmid	20127750
has license	no-cc
sha1sum (hex)	2464bf5348cb91e0a5a271f264dd4426f4e02a71
schema:url	https://doi.org/10.1002/rmv.638
resource representing a document's title	Viral infections associated with haemophagocytic syndrome
has PubMed Central identifier	PMC7169125
has PubMed identifier	20127750
schema:publication	Rev Med Virol
resource representing a document's body	covid:2464bf5348cb91e0a5a271f264dd4426f4e02a71#body_text
is schema:about of	named entity 'liver' named entity 'prompt' named entity 'antiviral therapy' named entity 'symptoms' named entity 'infiltration' named entity 'multiple' named entity 'ultimately' named entity 'EARLY RECOGNITION' named entity 'BONE MARROW TRANSPLANTATION' named entity 'DUE TO' named entity 'LABORATORY ABNORMALITIES' named entity 'UNTREATED' named entity 'ANTIVIRAL THERAPY' named entity 'RESULTS' named entity 'CYTOTOXIC T CELLS' named entity 'SPECIFIC' named entity 'PROMPT' named entity 'BROAD SPECTRUM' named entity 'RETICULOENDOTHELIAL SYSTEM' named entity 'INCLUDE' named entity 'MACROPHAGE ACTIVATION SYNDROME' named entity 'PROLIFERATION' named entity 'GROUP' named entity 'LYMPHADENOPATHY' named entity 'CAUSES' named entity 'INFECTIONS' named entity 'NK CELLS' named entity 'BEING' named entity 'group' named entity 'presentation' named entity 'cytokine' named entity 'commonly' named entity 'dysfunctions' named entity 'neurological' named entity 'aberrant' named entity 'Haemophagocytic syndrome' named entity 'HLH' named entity 'hepatomegaly' named entity 'immunosuppressive' named entity 'cases' named entity 'antimicrobials' named entity 'caused' named entity 'immunomodulatory' named entity 'viral infections' named entity 'reticuloendothelial' named entity 'Histiocytic' named entity 'malignancies' named entity 'immunosuppressive' named entity 'clinical features' named entity 'bone marrow transplantation' named entity 'herpes group' named entity 'immunocompetent' named entity 'TNF' named entity 'H5N1' named entity 'macrophages' named entity 'plasma' named entity 'lymphocytes' named entity 'IVIG' named entity 'histoplasmosis' named entity 'Southern blot' named entity 'cytotoxicity' named entity 'malignant disease' named entity 'cytokine' named entity 'infection' named entity 'H5N1' named entity 'Asian' named entity 'host organism' named entity 'up-regulation' named entity 'lymphoproliferation' named entity 'NK cell' named entity 'EBV' named entity 'viral load' named entity 'alpha chain' named entity 'lymphadenopathy' named entity 'prognosis' named entity 'genome' named entity 'EBV' named entity 'HLH'

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