About: Picornavirus uncoating intermediate captured in atomic detail

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Picornavirus uncoating intermediate captured in atomic detail
Creator	Rao, Zihe Fry, Elizabeth Gilbert, Robert Gao, Qiang Yin, Weidong Ren, Jingshan Wang, Junzhi Li, Xuemei Sun, Yao Axford, Danny Hu, Zhongyu Porta, Claudine Wang, Xiangxi Williams, Mark Zhao, Yuguang Stuart, David Walter, Thomas Mcauley, Katherine Rowlands, David
Source	PMC
abstract	It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are simple models for such viruses, and initiate this uncoating process through particle expansion, which reveals channels through which internal capsid proteins and the viral genome presumably exit the particle, although this has not been clearly seen until now. Here we present the atomic structure of an uncoating intermediate for the major human picornavirus pathogen CAV16, which reveals VP1 partly extruded from the capsid, poised to embed in the host membrane. Together with previous low-resolution results, we are able to propose a detailed hypothesis for the ordered egress of the internal proteins, using two distinct sets of channels through the capsid, and suggest a structural link to the condensed RNA within the particle, which may be involved in triggering RNA release.
has issue date	2013-06-03(xsd:dateTime)
bibo:doi	10.1038/ncomms2889
bibo:pmid	23728514
has license	cc-by-nc-nd
sha1sum (hex)	24709e4ba406a998d011ea9b31d33279bbabedb5
schema:url	https://doi.org/10.1038/ncomms2889
resource representing a document's title	Picornavirus uncoating intermediate captured in atomic detail
has PubMed Central identifier	PMC3709478
has PubMed identifier	23728514
schema:publication	Nat Commun
resource representing a document's body	covid:24709e4ba406a998d011ea9b31d33279bbabedb5#body_text
is schema:about of	named entity 'ARTICLE' named entity 'INTERMEDIATE' named entity 'ATOMIC' named entity 'HUMAN' named entity 'INTERNAL' named entity 'ATOMIC STRUCTURE' named entity 'SEEN' named entity 'PREVIOUS' named entity 'PATHOGEN' named entity 'HOST' named entity 'DETAILED' named entity 'RELEASE' named entity 'PARTICLE' named entity 'NON-' named entity 'MEMBRANE' named entity 'PICORNAVIRUS' named entity 'LARGELY' named entity 'EXTRUDED' named entity 'LINK' named entity 'UNCOATING' named entity 'INVOLVED' named entity 'PICORNAVIRUS' named entity 'VIRUSES' named entity 'EUKARYOTIC' named entity 'ACROSS' named entity 'USING' named entity 'HERE' named entity 'UNCOATING' named entity 'TRANSFERRED' named entity 'EMBED' named entity 'STRUCTURAL' named entity 'DISTINCT' named entity 'ORDERED' named entity 'PROCESS' named entity 'CONDENSED' named entity 'INITIATE' named entity 'SUGGEST' named entity 'HYPOTHESIS' named entity 'SIMPLE' named entity 'HOW' named entity 'VIRAL GENOME' named entity 'RESULTS' named entity 'CHANNELS' named entity 'MODELS' named entity 'GENOMES' named entity 'MAJOR' named entity 'HOST CELL' named entity 'POISED' named entity 'LOW' named entity 'INTERMEDIATE' named entity 'PRESENT' named entity 'PICORNAVIRUSES' named entity 'RESOLUTION' named entity 'PROTEINS' named entity 'EXIT' named entity 'MAY BE' named entity 'EXPANSION' named entity 'CAPSID' named entity 'VP1' named entity 'CAPSID PROTEINS' named entity 'RNA' named entity 'REVEALS' named entity 'TRIGGERING'

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