About: Preclinical septic shock research: why we need an animal ICU

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Preclinical septic shock research: why we need an animal ICU
Creator	Radermacher, Peter De Prost, Nicolas Azabou, Eric Guillon, Antoine Textoris, Julien Zafrani, Lara Jung, Boris Aboab, Jérôme Preau, Sebastien Silva, Stein Uhel, Fabrice Vodovar, Dominique
source	PMC
abstract	Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation into clinical practice has been disappointing. Classical animal models of septic shock usually involve one-sex-one-age animal models, mostly in mice or rats, contrasting with the heterogeneous population of septic shock patients. Many other factors limit the reliability of preclinical models and may contribute to preclinical research failure in critical care, including the host specificity of several pathogens, the fact that laboratory animals are raised in pathogen-free facilities and that organ support techniques are either absent or minimal. Advanced animal models have been developed with the aim of improving the clinical translatability of experimental findings. So-called animal ICUs refer to the preclinical investigation of adult or even aged animals of either sex, using—in case of rats and mice—miniaturized equipment allowing for reproducing an ICU environment at a small animal scale and integrating chronic comorbidities to more closely reflect the clinical conditions studied. Strength and limitations of preclinical animal models designed to decipher the mechanisms involved in septic cardiomyopathy are discussed. This article reviews the current status and the challenges of setting up an animal ICU.
has issue date	2019-06-10(xsd:dateTime)
bibo:doi	10.1186/s13613-019-0543-6
bibo:pmid	31183570
has license	cc-by
sha1sum (hex)	2496d5fe267b82a9633d89d0ebf8c4915888c470
schema:url	https://doi.org/10.1186/s13613-019-0543-6
resource representing a document's title	Preclinical septic shock research: why we need an animal ICU
has PubMed Central identifier	PMC6557957
has PubMed identifier	31183570
schema:publication	Ann Intensive Care
resource representing a document's body	covid:2496d5fe267b82a9633d89d0ebf8c4915888c470#body_text
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