About: The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes

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About: The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes
Creator	Koch, Egon Sabat, Robert Volk, Hans-Dieter Witte, Katrin Wolk, Kerstin
Source	Medline; PMC
abstract	Pelargonium sidoides is a medical herb and respective extracts are used very frequently for the treatment of respiratory tract infections. However, the effects of Pelargonium sidoides and a special extract prepared from its roots (EPs 7630) on human immune cells are not fully understood. Here we demonstrate that EPs 7630 induced a rapid and dose-dependent production of TNF-α, IL-6, and IL-10 by human blood immune cells. This EPs 7630-induced cytokine profile was more pro-inflammatory in comparison with the profile induced by viral or bacterial infection-mimicking agents. The search for EPs 7630 target cells revealed that T-cells did not respond to EPs 7630 stimulation by production of TNF-α, IL-6, or IL-10. Furthermore, pretreatment of T-cells with EPs 7630 did not modulate their TNF-α, IL-6, and IL-10 secretion during subsequent activation. In contrast to lymphocytes, monocytes showed clear intracellular TNF-α staining after EPs 7630 treatment. Accordingly, EPs 7630 predominantly provoked activation of MAP kinases and inhibition of p38 strongly reduced the monocyte TNF-α production. The pretreatment of blood immune cells with EPs 7630 lowered their secretion of TNF-α and IL-10 and caused an IL-6 dominant response during second stimulation with viral or bacterial infection-mimicking agents. In summary, we demonstrate that EPs 7630 activates human monocytes, induces MAP kinase-dependent pro-inflammatory cytokines in these cells, and specifically modulates their production capacity of mediators known to lead to an increase of acute phase protein production in the liver, neutrophil generation in the bone marrow, and the generation of adaptive Th17 and Th22 cells.
has issue date	2015-09-25(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0138075
bibo:pmid	26406906
has license	cc-by
sha1sum (hex)	24f4f393fb59daab089844e7af64e913d2951034
schema:url	https://doi.org/10.1371/journal.pone.0138075
resource representing a document's title	The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes
has PubMed Central identifier	PMC4583277
has PubMed identifier	26406906
schema:publication	PLoS One
resource representing a document's body	covid:24f4f393fb59daab089844e7af64e913d2951034#body_text
is schema:about of	named entity 'PRODUCTION CAPACITY' named entity 'SUMMARY' named entity 'UNDERSTOOD' named entity 'CONTRAST' named entity 'PRODUCTION' named entity 'INDUCED' named entity 'PRO-' named entity 'LIVER' named entity 'ACTIVATION' named entity 'SPECIAL' named entity 'RESPONSE' named entity 'ITS' named entity 'EXTRACT' named entity 'TH17' named entity 'FULLY' named entity 'INCREASE' named entity 'DEPENDENT' named entity 'BACTERIAL INFECTION' named entity 'VIRAL' named entity 'SUBSEQUENT' named entity 'CAUSED' named entity 'DID' named entity 'BONE MARROW' named entity 'STAINING' named entity 'IS A' named entity 'SECRETION' named entity 'HUMAN MONOCYTES' named entity 'PROVOKED' named entity 'THESE' named entity 'DOMINANT' named entity 'provoked' named entity 'liver' named entity 'induced' named entity 'cells' named entity 'frequently' named entity 'Pelargonium' named entity 'HUMAN MONOCYTES' named entity 'PELARGONIUM SIDOIDES' named entity 'KNOWN' named entity 'USED' named entity 'CYTOKINE PROFILE' named entity 'PREPARED' named entity 'ACUTE PHASE PROTEIN' named entity 'IL-10' named entity 'EFFECTS' named entity 'TREATMENT' named entity 'HUMAN BLOOD' named entity 'RESPOND TO' named entity 'MONOCYTES' named entity 'MAP KINASE' named entity 'DRIVES' named entity 'MAP KINASE' named entity 'PATHWAYS' named entity 'IMMUNE' named entity 'EPS 7630' named entity 'DEFENSE' named entity 'SELECTED' named entity 'ACTIVATING' named entity 'RAPID' named entity 'IL-10 SECRETION' named entity 'CELLS' named entity 'PROTEIN PRODUCTION' named entity 'MEDICAL' named entity 'ADAPTIVE' named entity 'MAP KINASES' named entity 'IMMUNE CELLS' named entity 'CLEAR' named entity 'FREQUENTLY' named entity 'CYTOKINES' named entity 'LOWERED' named entity 'ACTIVATES' named entity 'MODULATE' named entity 'BLOOD' named entity 'INHIBITION' named entity 'P38' named entity 'GENERATION' named entity 'SECOND'

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