About: Distinct infection process of SARS‐CoV‐2 in human bronchial epithelial cells line

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distinct infection process of SARS‐CoV‐2 in human bronchial epithelial cells line
Creator	Li, Qihan Liu, Longding Wang, Lichun Zhang, Ying Chen, Hongbo Guo, Lei Fan, Shengtao Dong, Xingqi Zhou, Xiaofang Zheng, Huiwen Jiang, Guorun Li, Dandan Li, Xueqi Liang, Yan Liao #, Yun Mou #, Tangwei Xie, Zhongping Xu, Xingli
source	Medline; PMC
abstract	COVID‐19, caused by SARS‐CoV‐2, leads to a series of clinical symptoms of respiratory and pulmonary inflammatory reactions via unknown pathologic mechanisms related to the viral infection process in tracheal or bronchial epithelial cells. Investigation of this viral infection in the human bronchial epithelial cell line (16HBE) suggests that SARS‐CoV‐2 can enter these cells through interaction between its membrane‐localized S protein with the ACE2 molecule on the host cell membrane. Further observation indicates distinct viral replication with a dynamic and moderate increase, whereby viral replication does not lead to a specific cytopathic effect but maintains a continuous release of progeny virions from infected cells. Although mRNA expression of various innate immune signaling molecules is altered in the cells, transcription of IFNα, IFNβ and IFNγ is unchanged. Furthermore, expression of some interleukins related to inflammatory reactions, such as IL‐6, IL‐2 and IL‐8, is maintained at low levels, whereas that of interleukins involved in immune regulation is upregulated. Interestingly, IL‐22, an interleukin that functions mainly in tissue repair, shows very high expression. Collectively, these data suggest a distinct infection process for this virus in respiratory epithelial cells, which may be linked to its clinicopathological mechanism. This article is protected by copyright. All rights reserved.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1002/jmv.26200
bibo:pmid	32558946
has license	no-cc
sha1sum (hex)	24fae0a0778a6a0d2d959b443c37904b20a08d86
schema:url	https://doi.org/10.1002/jmv.26200
resource representing a document's title	Distinct infection process of SARS‐CoV‐2 in human bronchial epithelial cells line
has PubMed Central identifier	PMC7323243
has PubMed identifier	32558946
schema:publication	J Med Virol
resource representing a document's body	covid:24fae0a0778a6a0d2d959b443c37904b20a08d86#body_text
is schema:about of	named entity 'bronchial' named entity 'symptoms' named entity 'expression' named entity 'lead' named entity 'interaction' named entity 'inflammatory' named entity 'Investigation' named entity 'host' named entity 'bronchial epithelial cells' named entity 'RELEASE' named entity 'release' named entity 'caused' named entity 'pulmonary' named entity 'mRNA' named entity 'innate immune' named entity 'cell membrane' named entity 'bronchial epithelial cells' named entity 'COVID' named entity 'immune regulation' named entity 'IFNα' named entity 'interleukins' named entity 'inflammatory reactions' named entity 'IFNβ' named entity 'mRNA expression' named entity 'ACE2' named entity 'cell membrane' named entity 'Infection' named entity 'SARS-CoV-2' named entity 'bronchial epithelial cells' named entity 'inoculated' named entity 'infectivity' named entity 'transcriptional' named entity 'interleukin' named entity 'immune regulation' named entity 'pattern recognition receptors' named entity 'ACE2' named entity 'viruses' named entity 'virus' named entity 'IL-2' named entity 'SARS-CoV-2' named entity 'innate immune response' named entity 'trachea' named entity 'IL-6' named entity 'causative agent' named entity 'antibody' named entity 'IFN' named entity 'fluorescence' named entity 'DMEM' named entity 'ACE2' named entity 'Virus' named entity 'respiratory tract' named entity 'clinical symptoms' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'TNF' named entity 'SARS-CoV-2' named entity 'fixed and stained' named entity 'clinical outcome' named entity 'host cell' named entity 'angiotensin-converting enzyme 2' named entity 'IL-8' named entity 'highly contagious' named entity 'Corning, NY' named entity 'ACE2'

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