About: Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement

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About: Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement
Creator	Wu, Jie Wu, Lili Liu, · Guo, · Chen, Zhongqing He, Guangting Huang, Qiaobing Li, Peixin Zhang, Weijin
source	Medline; PMC
abstract	Endoplasmic reticulum (ER) stress-induced endothelial cell (EC) apoptosis has been implicated in a variety of human diseases. In addition to being regarded as an NADPH oxidase (NOX) inhibitor, apocynin (APO) exhibits an anti-apoptotic effect in various cells. The present study aimed to identify the protective role of apocynin in ER stress-mediated EC apoptosis and the underlying mechanisms. We found that ER stress resulted in a significant increase in c-Jun N-terminal kinase phosphorylation, and elicited caspase 3 cleavage and apoptosis. However, apocynin obviously attenuated EC apoptosis and this effect was partly dependent on ER stress sensor inositol-requiring enzyme 1α (IRE1α). Importantly, apocynin upregulated IRE1α expression in both protein and mRNA levels and promoted the pro-survival XBP1 splicing. Our results suggest that apocynin protects ECs against ER stress-induced apoptosis via IRE1α involvement. These findings may provide a novel mechanistic explanation for the anti-apoptotic effect of apocynin in ER stress.
has issue date	2018-04-25(xsd:dateTime)
bibo:doi	10.1007/s11010-018-3362-4
bibo:pmid	29696609
has license	no-cc
sha1sum (hex)	2507c1c709d7a1afa0ae0bcbf08bef3851e04c50
schema:url	https://doi.org/10.1007/s11010-018-3362-4
resource representing a document's title	Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement
has PubMed Central identifier	PMC7088535
has PubMed identifier	29696609
schema:publication	Mol Cell Biochem
resource representing a document's body	covid:2507c1c709d7a1afa0ae0bcbf08bef3851e04c50#body_text
is schema:about of	named entity 'enzyme' named entity 'NOX' named entity 'splicing' named entity 'caspase' named entity 'Apocynin' named entity 'CLEAVAGE' named entity 'MECHANISTIC EXPLANATION' named entity 'TO IDENTIFY' named entity 'ER STRESS SENSOR' named entity 'THESE' named entity 'IRE1' named entity 'STUDY' named entity 'ER STRESS' named entity 'C-JUN N-TERMINAL KINASE' named entity 'ENDOTHELIAL CELL' named entity 'PROTECTIVE ROLE' named entity 'CELLS' named entity 'ELICITED' named entity 'VARIOUS' named entity 'PRESENT' named entity 'ANTI-APOPTOTIC EFFECT' named entity 'SIGNIFICANT' named entity 'ECS' named entity 'MEDIATED' named entity 'APOCYNIN' named entity 'ENDOPLASMIC RETICULUM STRESS-INDUCED APOPTOSIS' named entity 'ENGAGEMENT' named entity 'IRE1' named entity 'PHOSPHORYLATION' named entity 'OUR' named entity 'EFFECT' named entity 'ENDOPLASMIC RETICULUM' named entity 'INVOLVEMENT' named entity 'NADPH OXIDASE' named entity 'CASPASE 3' named entity 'XBP1 SPLICING' named entity 'INDUCED' named entity 'EXHIBITS' named entity 'ATTENUATED' named entity 'RESULTS' named entity 'ENDOTHELIAL CELLS' named entity 'APOPTOSIS' named entity 'NOVEL' named entity 'EXPRESSION' named entity 'HUMAN DISEASES' named entity 'UPREGULATED' named entity 'PROVIDE' named entity 'LEVELS' named entity 'MECHANISMS' named entity 'ADDITION' named entity 'UNDERLYING' named entity 'STRESS' named entity 'FINDINGS' named entity 'INCREASE' named entity 'DEPENDENT' named entity 'SUGGEST' named entity 'BEING' named entity 'INHIBITOR' named entity 'PRO-SURVIVAL' named entity 'INOSITOL-REQUIRING ENZYME 1' named entity 'PROTEIN ' named entity 'APOCYNIN' named entity 'MRNA' named entity 'VARIETY' named entity 'ER STRESS-INDUCED APOPTOSIS' covid:arg/2507c1c709d7a1afa0ae0bcbf08bef3851e04c50 named entity 'mechanistic' named entity 'ER stress' named entity 'protein' named entity 'inhibitor' named entity 'levels' named entity 'mRNA' named entity 'apocynin'

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