About: Expanded encyclopaedias of DNA elements in the human and mouse genomes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expanded encyclopaedias of DNA elements in the human and mouse genomes
Creator	Zhang, Jing Wang, Xiaofeng Gilbert, David Williams, Brian Ecker, Joseph White, Kevin Adrian, Jessika Burge, Christopher Chhetri, Surya Davis, Carrie Dekker, Job Dickel, Diane Dobin, Alexander Elhajjajy, Shaimae Epstein, Charles Farnham, Peggy Guigó, Roderic Huey, Jack Kawli, Trupti Keller, Cheryl Kellis, Manolis Klein, Robert Kundaje, Anshul Lécuyer, Eric Mendenhall, Eric Moore, Jill Mortazavi, Ali Noble, William Pauli-Behn, Florencia Pratt, Henry Purcaro, Michael Rinn, John Rivera-Mulia, Juan Rozowsky, Joel Shoresh, Noam Snetkova, Valentina Visel, Axel Victorsen, Alec Wei, Xintao Yeo, Gene Zhang, Jialing Zhang, Xiao-Ou
Source	PMC
abstract	The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE(1) and Roadmap Epigenomics(2) data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1038/s41586-020-2493-4
bibo:pmid	32728249
has license	cc-by
sha1sum (hex)	255948ac432c7f0ab0f4c9167f9c29800c42def9
schema:url	https://doi.org/10.1038/s41586-020-2493-4
resource representing a document's title	Expanded encyclopaedias of DNA elements in the human and mouse genomes
has PubMed Central identifier	PMC7410828
has PubMed identifier	32728249
schema:publication	Nature
resource representing a document's body	covid:255948ac432c7f0ab0f4c9167f9c29800c42def9#body_text
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