About: Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

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About: Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
Creator	Hung, Tao Deng, Yao Tan, Wenjie Wang, Wen Lan, Jiaming Chen, Hong Guo, Xiaojuan Lu, Zhuozhuang Zou, Xiaohui
source	Medline; PMC
abstract	An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the in vivo systemic and mucosal antigen-specific immune responses induced by a single intramuscular or intragastric administration of recombinant adenoviral type 5 (Ad5) or type 41 (Ad41) -based vaccines expressing the MERS-CoV spike (S) protein. Intragastric administration of either Ad5-S or Ad41-S induced antigen-specific IgG and neutralizing antibody in serum; however, antigen-specific T-cell responses were not detected. In contrast, after a single intramuscular dose of Ad5-S or Ad41-S, functional antigen-specific T-cell responses were elicited in the spleen and pulmonary lymphocytes of the mice, which persisted for several months. Both rAd-based vaccines administered intramuscularly induced systemic humoral immune responses (neutralizing IgG antibodies). Our results show that a single dose of Ad5-S- or Ad41-S-based vaccines represents an appealing strategy for the control of MERS-CoV infection and transmission.
has issue date	2015-04-21(xsd:dateTime)
bibo:doi	10.1111/imm.12462
bibo:pmid	25762305
has license	green-oa
sha1sum (hex)	25fb4884567c7d5d80e42fca0b057e93a8fb19db
schema:url	https://doi.org/10.1111/imm.12462
resource representing a document's title	Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
has PubMed Central identifier	PMC4515128
has PubMed identifier	25762305
schema:publication	Immunology
resource representing a document's body	covid:25fb4884567c7d5d80e42fca0b057e93a8fb19db#body_text
is schema:about of	named entity 'MERS-CoV' named entity 'infection' named entity 'spike (S) protein' named entity 'neutralizing antibody' named entity 'mice' named entity 'lymphocytes' named entity 'spleen' named entity 'immune responses' named entity 'serum' named entity 'vaccines' named entity 'antigen' named entity 'Middle East respiratory syndrome coronavirus' named entity 'lentiviral' named entity 'Middle East respiratory syndrome coronavirus' named entity 'spleens' named entity 'viruses' named entity 'MERS' named entity 'vaccination' named entity 'Adenovirus' named entity 'peptide library' named entity 'vaccination' named entity 'San Jose' named entity 'antibody' named entity 'perfusing' named entity 'recombinant' named entity 'preventive vaccine' named entity 'Adenovirus' named entity 'peptides' named entity 'SARS-CoV' named entity 'intramuscular' named entity 'agarose gel' named entity 'RBD' named entity 'epithelium' named entity 'Mucosal immunity' named entity 'titre' named entity 'MERS-CoV' named entity 'immunofluorescence assays' named entity 'lymphocytes' named entity 'antibody' named entity 'MERS-CoV' named entity 'receptor' named entity 'Tween 20' named entity 'MERS-CoV' named entity 'epithelium' named entity 'lymphocytes' named entity 'vaccination' named entity 'MERS-CoV' named entity 'reporter gene' named entity 'antibodies' named entity 'West Grove' named entity 'log phase' named entity 'nucleotide sequence' named entity 'incubation' named entity 'T-cell' named entity 'MERS-CoV' named entity 'infection' named entity 'CD8 T cells' named entity 'vaccination' named entity 'immunization' named entity 'viruses' named entity 'MERS-CoV' named entity 'intramuscular' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'vector' named entity 'cytokine secretion' named entity 'recombinant' named entity 'IL-6' named entity 'antigen' named entity 'serum' named entity 'amino acids' named entity 'tropism' named entity 'recombinant'

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