About: Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
Creator	Uversky, Vladimir Chandra Verma, Navneet Mishra, Pushpendra Nandi, Chayan Rao, Chethana
Source	Elsevier; Medline; PMC
abstract	Abstract Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be distinguished from other proteins in terms of lack of any fixed structure. Such dynamic behavior of IDPs earned the name “Dancing Proteins.” The exploration of these dancing proteins in viruses has just started and crucial details such as correlation of rapid evolution, high rate of mutation and accumulation of disordered contents in viral proteome at least understood partially. In order to gain a complete understanding of this correlation, there is a need to decipher the complexity of viral mediated cell hijacking and pathogenesis in the host organism. Further there is necessity to identify the specific patterns within viral and host IDPs such as aggregation; Molecular recognition features (MoRFs) and their association to virulence, host range and rate of evolution of viruses in order to tackle the viral-mediated diseases. The current book chapter summarizes the aforementioned details and suggests the novel opportunities for further research of IDPs senses in viruses.
has issue date	2020-04-02(xsd:dateTime)
bibo:doi	10.1016/bs.pmbts.2020.03.001
bibo:pmid	32828463
has license	els-covid
sha1sum (hex)	2636c0ce0e415a04014e0223876d05a4dbeff83a
schema:url	https://doi.org/10.1016/bs.pmbts.2020.03.001
resource representing a document's title	Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
has PubMed Central identifier	PMC7129803
has PubMed identifier	32828463
schema:publication	Prog Mol Biol Transl Sci
resource representing a document's body	covid:2636c0ce0e415a04014e0223876d05a4dbeff83a#body_text
is schema:about of	named entity 'cell' named entity 'pathogenesis' named entity 'Intrinsically disordered proteins' named entity 'bound state' named entity 'solubility' named entity 'viruses' named entity 'Capsid' named entity 'nucleic acid' named entity 'viral genome' named entity 'nucleoprotein' named entity 'viruses' named entity 'cell transformation' named entity 'icosahedral structure' named entity 'viruses' named entity 'proteolysis' named entity 'Semliki forest virus' named entity 'HPV' named entity 'cellular machinery' named entity 'gene' named entity 'viruses' named entity 'HIV' named entity 'signaling pathways' named entity 'viral particle' named entity 'IDP' named entity 'gene' named entity 'ssRNA' named entity 'zinc finger domain' named entity 'proteolysis' named entity 'virus' named entity 'phosphorylation sites' named entity 'denatured' named entity 'polycistronic' named entity 'central cavity' named entity 'icosahedral' named entity 'P. falciparum' named entity 'viruses' named entity 'Molecular recognition' named entity 'post-translational cleavage' named entity 'amino acids' named entity 'protein' named entity 'eukaryotes' named entity 'primate' named entity 'amino acids' named entity 'Coronavirus' named entity 'reading frames' named entity 'phosphoprotein' named entity 'intrinsically disordered' named entity 'Mycoplasma' named entity 'viruses' named entity 'MeV' named entity 'IDPs' named entity 'Nucleoprotein complex' named entity 'nucleus' named entity 'replication cycle' named entity 'Bcl-XL' named entity 'nonvirulent' named entity 'halophilic' named entity 'nucleocapsid' named entity 'Cyclosporin' named entity 'complement' named entity 'molecular mass' named entity 'host cell' named entity 'intrinsically disordered protein' named entity 'membrane proteins' named entity 'cell cycle' named entity 'RNA synthesis' named entity 'C-terminal region' named entity 'secondary structures' named entity 'host cell' named entity 'motif' named entity 'alternative splicing' named entity 'Hemagglutinin' named entity 'machine learning' named entity 'virulence' named entity 'viruses' named entity 'developmental processes' named entity 'protein'

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