About: Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves

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About: Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves
Creator	Loy, John Clawson, Michael Kuehn, Larry Mcdaneld, Tara Workman, Aspen
Source	Medline; PMC
abstract	BACKGROUND: Bovine coronavirus (BCV) is associated with respiratory infections in cattle of all ages; however, a temporal study to evaluate the effect of BCV immunity on virus shedding and bovine respiratory disease (BRD) incidence in pre-weaned beef calves has not been reported. Thus, we report here a prospective study in three herds of crossbred beef calves (n = 817) with endemic BCV. Serial blood samples for measurement of serum anti-BCV antibody titers and nasal swabs for detection of BCV and other common viral and bacterial BRD pathogens were collected from all calves or subsets of calves at predetermined times from birth through weaning. The calves were monitored for BRD and those that developed signs of respiratory disease were sampled for diagnostic testing. To discover additional risk factors that could have influenced BRD development, sequence analysis of the BCV strain(s) circulating in each herd, and the prevalence of common opportunistic bacterial pathogens in the upper respiratory tract of sick and apparently healthy cattle were also evaluated. RESULTS: Two hundred forty-eight of the 817 study calves (30.4%) were treated for BRD prior to weaning; 246 of those were from a single herd involved in two outbreaks of BRD leading to mass treatment of all calves in that group. Molecular diagnostic testing found BCV and Histophilus somni in nasal swabs taken at the time of BRD treatment. Between herd analyses revealed anti-BCV serum antibody abundance did not associate with the incidence of BRD or BCV shedding, though these measurements may have been hindered by the long periods between sample collections. Analysis of the BCV spike gene hypervariable region revealed four polymorphisms in 15 isolates from the three herds, making strain variation unlikely to account for differences in treatment rates between herds. Persistent or recurrent shedding episodes of BCV occurred in some animals treated for BRD. CONCLUSION: Co-detection of BCV and H. somni at the time of the disease outbreak suggests that these pathogens contributed to disease pathogenesis. Developing appropriate control measures for respiratory BCV infections may help decrease the incidence of pre-weaning BRD. The role of antibodies in protection must still be further defined. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-019-1887-8) contains supplementary material, which is available to authorized users.
has issue date	2019-05-22(xsd:dateTime)
bibo:doi	10.1186/s12917-019-1887-8
bibo:pmid	31118011
has license	cc-by
sha1sum (hex)	26762988147d906e873f16c6e03cbb2ad7c46ea1
schema:url	https://doi.org/10.1186/s12917-019-1887-8
resource representing a document's title	Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves
has PubMed Central identifier	PMC6532244
has PubMed identifier	31118011
schema:publication	BMC Vet Res
resource representing a document's body	covid:26762988147d906e873f16c6e03cbb2ad7c46ea1#body_text
is schema:about of	named entity 'blood samples' named entity 'BRD' named entity 'virus shedding' named entity 'evaluated' named entity 'bacterial pathogens' named entity 'titers' named entity 'virus shedding' named entity 'CALVES' named entity 'BEEF' covid:arg/26762988147d906e873f16c6e03cbb2ad7c46ea1 named entity 'VIRAL AND' named entity 'PROSPECTIVE STUDY' named entity 'STUDY' named entity 'MONITORED' named entity 'WEANED' named entity 'SIGNS' named entity 'SEQUENCE ANALYSIS' named entity 'PREVALENCE' named entity 'CALVES' named entity 'APPARENTLY' named entity '28S' named entity 'HAVE' named entity 'ENDEMIC' named entity 'RISK FACTORS' named entity 'BOVINE RESPIRATORY DISEASE' named entity 'CATTLE' named entity 'FROM BIRTH' named entity 'DISCOVER' named entity 'BACTERIAL' named entity 'SICK' named entity 'BLOOD SAMPLES' named entity 'PRE' named entity 'BEEF' named entity 'TREATMENT' named entity 'BOVINE CORONAVIRUS' named entity 'INCIDENCE' named entity 'BACTERIAL PATHOGENS' named entity 'NASAL SWABS' named entity 'REPORTED' named entity 'VIRUS SHEDDING' named entity 'EFFECT' named entity 'ADDITIONAL' named entity 'COMMON' named entity 'SERIAL' named entity 'ANTIBODY TITERS' named entity 'DEVELOPMENT' named entity 'HERE' named entity 'PRE' named entity 'COLLECTED' named entity 'EVALUATE' named entity 'TIMES' named entity 'HERD' named entity 'MEASUREMENT' named entity 'PREDETERMINED' named entity 'STRAIN' named entity 'SAMPLED' named entity 'BRD' named entity 'DIAGNOSTIC TESTING' named entity 'BACKGROUND' named entity 'RESPIRATORY INFECTIONS' named entity 'ALL AGES' named entity 'RESPIRATORY DISEASE' named entity 'IMMUNITY' named entity 'HEALTHY' named entity 'CIRCULATING' named entity 'UPPER RESPIRATORY TRACT' named entity 'HUMORAL IMMUNITY' named entity 'PATHOGENS' named entity 'DETECTION' named entity 'BOVINE CORONAVIRUS' named entity 'TEMPORAL' named entity 'WEANING' named entity 'BOVINE RESPIRATORY DISEASE' named entity 'WEANED' named entity 'VIRUS SHEDDING' named entity 'REPORT' named entity 'LONGITUDINAL STUDY'

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