About: The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo

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About: The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo
Creator	Fan, Yunpeng Guo, Zhenhuan Liu, Yonglu Ma, Xia Shen, Zhiqiang Wang, Jinliang
topic	covid:26d93683447b88c154664f5f80b35cd7991ba106#this
source	Medline; PMC
abstract	Objectives. The present study was conducted to evaluate the activity of nanometer propolis flavone (NPF) on inhibiting porcine parvovirus (PPV) in vitro and in vivo. Methods. In vitro, the effect of NPF on cellular infectivity of PPV was carried out before and after adding drug and simultaneous adding and PPV after being mixed. In vivo, the anti-PPV effect of NPF in guinea pigs was performed. Results. The results showed that NPF could significantly inhibit PPV infecting porcine kidney- (PK-) 15 cells compared with propolis flavone (PF), and the activity of NPF was the best in preadding drug pattern. NPF at high and medium doses was able to observably restrain PPV copying in lung, gonad, blood, and spleen, decrease the impact of PPV on weight of guinea pigs, and improve hemagglutination inhibition (HI) of PPV in serum. In addition, it could also increase the contents of IL-2 and IL-6 in serum after PPV challenge. Conclusion. These results indicated that NPF could significantly improve the anti-PPV activity of PF, and its high concentration possessed the best efficacy. Therefore, NPF would be expected to be exploited into a new-style antiviral drug.
has issue date	2015-02-26(xsd:dateTime)
bibo:doi	10.1155/2015/472876
bibo:pmid	25815034
has license	cc-by
sha1sum (hex)	26d93683447b88c154664f5f80b35cd7991ba106
schema:url	https://doi.org/10.1155/2015/472876
resource representing a document's title	The Anti-Porcine Parvovirus Activity of Nanometer Propolis Flavone and Propolis Flavone In Vitro and In Vivo
has PubMed Central identifier	PMC4357139
has PubMed identifier	25815034
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:26d93683447b88c154664f5f80b35cd7991ba106#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/26d93683447b88c154664f5f80b35cd7991ba106
is schema:about of	named entity 'doses' named entity 'compared' named entity 'antiviral drug' named entity 'NPF' named entity 'expected' named entity 'adding' named entity 'vivo' named entity 'serum' named entity 'IL-6' named entity 'Propolis' covid:arg/26d93683447b88c154664f5f80b35cd7991ba106 named entity 'concentration' named entity 'activity' named entity 'serum' named entity 'activity' named entity 'hemagglutination inhibition' named entity 'flavone' named entity 'carried' named entity 'performed' named entity 'flavone' named entity 'NPF' named entity 'NPF' named entity 'hemagglutination inhibition' named entity 'Flavone' named entity 'Nanometer' named entity 'guinea pigs' named entity 'primary antibodies' named entity 'NPF' named entity 'sterilization' named entity 'NPF' named entity 'gonad' named entity 'IFN' named entity 'China' named entity 'biological activities' named entity 'Viral' named entity 'NPF' named entity 'IFN' named entity 'live cells' named entity 'guinea pig' named entity 'NPF' named entity 'hepatoprotection' named entity 'serum' named entity 'NPF' named entity 'secretion' named entity 'serum' named entity 'control group' named entity 'liver' named entity 'lymph nodes' named entity 'control group' named entity 'nanotechnology' named entity 'antiviral effect' named entity 'control group' named entity 'humoral immune response' named entity 'NPF' named entity 'transmissible spongiform encephalopathy' named entity 'NPF' named entity 'NPF' named entity 'serum samples' named entity 'NPF' named entity 'DMSO' named entity 'spleen' named entity 'cell group' named entity 'Cytokine' named entity 'Propolis' named entity 'serum' named entity 'Th1' named entity 'sterilization' named entity 'spleen' named entity 'gonad' named entity 'guinea pigs' named entity 'biological functions' named entity 'Shandong Province' named entity 'vaccination' named entity 'Titre'

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