About: Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2

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About: Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2
Creator	Campos, Samuel
Source	PMC
abstract	Since 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell nucleus, relying on myriad host cell proteins and processes. The major breakthrough finding from these recent endeavors has been the realization of L2-dependent utilization of cellular sorting factors for the retrograde transport of vDNA away from degradative endo/lysosomal compartments to the Golgi, prior to mitosis-dependent nuclear accumulation of L2/vDNA. An overview of current models of HPV entry, subcellular trafficking, and the role of L2 during initial infection is provided below, highlighting unresolved questions and gaps in knowledge.
has issue date	2017-12-03(xsd:dateTime)
bibo:doi	10.3390/v9120370
bibo:pmid	29207511
has license	cc-by
sha1sum (hex)	26f219a1d536118b973f8948cd564b53beb649fe
schema:url	https://doi.org/10.3390/v9120370
resource representing a document's title	Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2
has PubMed Central identifier	PMC5744145
has PubMed identifier	29207511
schema:publication	Viruses
resource representing a document's body	covid:26f219a1d536118b973f8948cd564b53beb649fe#body_text
is schema:about of	named entity 'HPV' named entity 'factors' named entity 'cell' named entity 'evolved' named entity 'REALIZATION' named entity 'ITS' named entity 'EVOLVED' named entity 'HOST CELL' named entity 'COMPARTMENTS' named entity 'CELL NUCLEUS' named entity 'ENTRY' named entity 'PROVIDED' named entity 'KNOWLEDGE' named entity 'INITIAL' named entity 'SHIFT' named entity 'ROLE' named entity 'NUCLEAR' named entity 'ACCUMULATION' named entity 'MAJOR' named entity 'THESE' named entity 'BREAKTHROUGH' named entity 'PROTEIN ' named entity 'GOLGI' named entity 'HUMAN PAPILLOMAVIRUS ' named entity 'RETROGRADE TRANSPORT' named entity 'MEANS' named entity 'TRAFFICKING' named entity 'MULTIPLE' named entity 'CURRENT' named entity 'REVEALED' named entity 'LABORATORIES' named entity 'TO DELIVER' named entity 'PRIOR TO' named entity 'INFECTION' named entity 'MINOR' named entity 'INFECTION' named entity 'ABILITIES' named entity 'INITIAL' named entity 'TRAFFICKING' named entity 'PAPILLOMAVIRUS' named entity 'OUR' named entity 'HIGHLIGHTING' named entity 'VIRAL GENOME' named entity 'MITOSIS' named entity 'THE CELL' named entity 'RECENT' named entity 'MODELS' named entity 'ENDO' named entity 'GAPS' named entity 'PROCESSES' named entity 'OVERVIEW' named entity 'SORTING' named entity 'CAPSID PROTEIN' named entity 'CELLULAR' named entity 'UNRESOLVED' named entity 'UTILIZATION' named entity 'UNDERSTANDING' named entity 'GENOME' named entity 'HPV' named entity 'PARADIGM' named entity 'UNIQUE' named entity 'DEPENDENT' named entity 'AWAY' named entity 'WORK' named entity 'FINDING' named entity 'PROTEINS' named entity 'infection' named entity 'cellular' named entity 'myriad' named entity 'cell nucleus' named entity 'highlighting' named entity 'sorting' named entity 'paradigm shift' named entity 'initial infection' named entity 'human papillomavirus' named entity 'Genome' named entity 'peptide' named entity 'gamma secretase' named entity 'virion' named entity 'SUMO' named entity 'Endocytosis'

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