About: Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease

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About: Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease
Creator	Kalantar-Zadeh, Kamyar Streja, Elani Gov, Cooke, Joanne Ferrey, Antoney Hanna, Ramy Rhee, Connie Tantisattamo, Ekamol Brown-Tortorici, Amanda Chen, Joline Crowley, Susan Donnelly, Meghan Joshi, Shivam Kovesdy, Csaba Lau, Wei-Ling Malik, Shaista Nguyen, Danh Schlueter, Rebecca Schulman, Sherry Crowley@va, Susan
Source	Medline; PMC
abstract	Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U.S. Government Executive Order seek to implement strategies that reduce the burden of kidney failure by slowing CKD progression and controlling uremia without dialysis. Pragmatic dietary interventions may have a role in improving CKD outcomes and preventing or delaying dialysis initiation. Evidence suggests that a patient-centered plant-dominant low-protein diet (PLADO) of 0.6–0.8 g/kg/day composed of >50% plant-based sources, administered by dietitians trained in non-dialysis CKD care, is promising and consistent with the precision nutrition. The scientific premise of the PLADO stems from the observations that high protein diets with high meat intake not only result in higher cardiovascular disease risk but also higher CKD incidence and faster CKD progression due to increased intraglomerular pressure and glomerular hyperfiltration. Meat intake increases production of nitrogenous end-products, worsens uremia, and may increase the risk of constipation with resulting hyperkalemia from the typical low fiber intake. A plant-dominant, fiber-rich, low-protein diet may lead to favorable alterations in the gut microbiome, which can modulate uremic toxin generation and slow CKD progression, along with reducing cardiovascular risk. PLADO is a heart-healthy, safe, flexible, and feasible diet that could be the centerpiece of a conservative and preservative CKD-management strategy that challenges the prevailing dialysis-centered paradigm.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.3390/nu12071931
bibo:pmid	32610641
has license	cc-by
sha1sum (hex)	270b02d191b565aea576d879fc00f9c6b71e14e9
schema:url	https://doi.org/10.3390/nu12071931
resource representing a document's title	Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease
has PubMed Central identifier	PMC7400005
has PubMed identifier	32610641
schema:publication	Nutrients
resource representing a document's body	covid:270b02d191b565aea576d879fc00f9c6b71e14e9#body_text
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