About: Amending Koch’s postulates for viral disease: when “growth in pure culture” leads to a loss of virulence

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Amending Koch’s postulates for viral disease: when “growth in pure culture” leads to a loss of virulence
Creator	Feldmann, Heinz Safronetz, David Prescott, Joseph
Source	Elsevier; Medline; PMC
abstract	It is a common laboratory practice to propagate viruses in cell culture. While convenient, these methodologies often result in unintentional genetic alterations, which have lead to adaptation and even attenuation in animal models of disease. An example is the attenuation of hantaviruses (family: Bunyaviridae, genus: Hantavirus) when cultured in vitro. In this case, viruses propagated in the natural reservoir species cause disease in nonhuman primates that closely mimics the human disease, but passaging in cell culture attenuates these viruses to the extent that do not cause any measurable disease in nonhuman primates. As efforts to develop animal models progress, it will be important to take into account the influences that culture in vitro may have on the virulence of viruses. In this review we discuss this phenomenon in the context of past and recent examples in the published literature.
has issue date	2017-01-01(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2016.11.002
bibo:pmid	27832942
has license	green-oa
sha1sum (hex)	27535dab71e7eeb897ac1837f901d295cd5aaf66
schema:url	https://doi.org/10.1016/j.antiviral.2016.11.002
resource representing a document's title	Amending Koch’s postulates for viral disease: when “growth in pure culture” leads to a loss of virulence
has PubMed Central identifier	PMC5182102
has PubMed identifier	27832942
schema:publication	Antiviral Research
resource representing a document's body	covid:27535dab71e7eeb897ac1837f901d295cd5aaf66#body_text
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