About: Production of IFN-β during Listeria monocytogenes Infection Is Restricted to Monocyte/Macrophage Lineage

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About: Production of IFN-β during Listeria monocytogenes Infection Is Restricted to Monocyte/Macrophage Lineage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Production of IFN-β during Listeria monocytogenes Infection Is Restricted to Monocyte/Macrophage Lineage
Creator	Lienenklaus, Stefan Jablonska, Jadwiga Solodova, Evgenia Weiss, Siegfried
Source	PMC
abstract	The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primary member of type I IFN that initiates a cascade of IFN-α production. Here we addressed the question which cells are responsible for IFN-β expression after infection with the intracellular pathogen Listeria monocytogenes by using a genetic approach. By means of newly established reporter mice, maximum of IFN-β expression was observed at 24 hours post infection in spleen and, surprisingly, 48 hours post infection in colonized cervical and inguinal lymph nodes. Colonization of lymph nodes was independent of the type I IFN signaling, as well as bacterial dose and strain. Using cell specific reporter function and conditional deletions we could define cells expressing LysM as the major IFN-β producers, with cells formerly defined as Tip-DCs being the highest. Neutrophilic granulocytes, dendritic cells and plasmacytoid dendritic cells did not significantly contribute to type I IFN production.
has issue date	2011-04-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0018543
bibo:pmid	21494554
has license	cc-by
sha1sum (hex)	27548472c288a185911a8907c927d18f3c9b0abe
schema:url	https://doi.org/10.1371/journal.pone.0018543
resource representing a document's title	Production of IFN-β during Listeria monocytogenes Infection Is Restricted to Monocyte/Macrophage Lineage
has PubMed Central identifier	PMC3073975
has PubMed identifier	21494554
schema:publication	PLoS One
resource representing a document's body	covid:27548472c288a185911a8907c927d18f3c9b0abe#body_text
is schema:about of	named entity 'IFN-a' named entity 'type I interferons' named entity 'detrimental' named entity 'expressing' named entity 'type I IFN' named entity 'Colonization' named entity 'LISTERIA MONOCYTOGENES INFECTION' named entity 'POST' named entity 'PRIMARY' named entity 'BACTERIAL INFECTIONS' named entity 'OBSERVED' named entity 'APPROACH' named entity 'RESPONSIBLE' named entity 'DEFINED' named entity 'NEUTROPHILIC' named entity 'PATHOGEN' named entity 'VIRAL PATHOGENS' named entity 'BEING' named entity 'GENETIC' named entity 'CONDITIONAL' named entity 'INFECTION' named entity 'DOSE' named entity 'CYTOKINES' named entity 'LYSM' named entity 'MICE' named entity 'NON-' named entity 'TYPE I INTERFERONS' named entity 'FAMILY' named entity 'SIGNALING' named entity 'CASCADE' named entity 'REPORTER' named entity '48 HOURS' named entity 'DCS' named entity 'BACTERIAL' named entity 'NEWLY' named entity 'QUESTION' named entity 'VIRUSES' named entity 'COURSE' named entity 'IFN' named entity 'MEANS' named entity 'TYPE I IFN PRODUCTION' named entity 'PLASMACYTOID' named entity 'DID' named entity 'CELL' covid:arg/27548472c288a185911a8907c927d18f3c9b0abe named entity '24 HOURS' named entity 'INGUINAL LYMPH NODES' named entity 'PRODUCTION' named entity 'COLONIZATION' named entity 'CONTRIBUTE ' named entity 'IFN' named entity 'LINEAGE' named entity 'MONOCYTE' named entity 'RESTRICTED' named entity 'CELLS' named entity 'EXPRESSION' named entity 'LYMPH NODES' named entity 'STIMULATION' named entity 'MAJOR' named entity 'MAXIMUM' named entity 'TIP' named entity 'ESTABLISHED' named entity 'SPLEEN' named entity 'COULD BE' named entity 'HERE' named entity 'BUT' named entity 'DENDRITIC CELLS' named entity 'PRODUCTION' named entity 'IFN-A' named entity 'INTRACELLULAR' named entity 'TYPE I' named entity 'SPECIFIC' named entity 'PRODUCERS' named entity 'FUNCTION' named entity 'BENEFICIAL' named entity 'USING' named entity 'THESE' named entity 'GRANULOCYTES'

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