About: Lower Respiratory Tract Virus Findings in Mechanically Ventilated Patients With Severe Community-Acquired Pneumonia

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lower Respiratory Tract Virus Findings in Mechanically Ventilated Patients With Severe Community-Acquired Pneumonia
Creator	Ala-Kokko, T Syrjälä, H Vuorinen, T Karhu, J Ohtonen, P
Source	Medline; PMC
abstract	Background. The role of viral infections in the etiology of severe community-acquired pneumonia (SCAP) was prospectively evaluated from 2008 to 2012 at a university-level intensive care unit. Methods. Clinical data and microbiological tests were assessed: blood cultures, urine pneumococcal and legionella antigens, Mycoplasma pneumoniae and Chlamydia pneumoniae antibodies from paired serums, and respiratory virus detection by multiplex, real-time polymerase chain reaction (PCR) from nasopharyngeal swabs and lower tracheal specimens via intubation tube. Results. Of 49 mechanically ventilated SCAP patients (21 men and 28 women; median age, 54 years), the etiology was identified in 45 cases (92%). There were 21 pure bacterial infections (43%), 5 probably pure viral infections (10%), and 19 mixed bacterial–viral infections (39%), resulting in viral etiology in 24 patients (49%). Of 26 viruses, 21 (81%) were detected from bronchial specimens and 5 (19%) from nasopharyngeal swabs. Rhinovirus (15 cases, 58%) and adenovirus (4 cases, 15%) were the most common viral findings. The bacterial–viral etiology group had the highest peak C-reactive protein levels (median, 356 [25th–75th percentiles, 294–416], P = .05), whereas patients with probably viral etiology had the lowest peak procalcitonin levels (1.7 [25th–75th percentiles, 1.6–1.7]). The clinical characteristics of pure bacterial and mixed bacterial–viral etiologies were comparable. Hospital stay was longest among the bacterial group (17 vs 14 days; P = .02). Conclusions. Viral findings were demonstrated in almost half of the SCAP patients. Clinical characteristics were similar between the pure bacterial and mixed bacterial–viral infections groups. The frequency of viral detection depends on the availability of PCR techniques and lower respiratory specimens.
has issue date	2014-04-11(xsd:dateTime)
bibo:doi	10.1093/cid/ciu237
bibo:pmid	24729498
has license	bronze-oa
sha1sum (hex)	2773edf2734f65d63b4c83a727bbda6d3f23c380
schema:url	https://doi.org/10.1093/cid/ciu237
resource representing a document's title	Lower Respiratory Tract Virus Findings in Mechanically Ventilated Patients With Severe Community-Acquired Pneumonia
has PubMed Central identifier	PMC4305142
has PubMed identifier	24729498
schema:publication	Clinical Infectious Diseases
resource representing a document's body	covid:2773edf2734f65d63b4c83a727bbda6d3f23c380#body_text
is schema:about of	named entity 'See' named entity 'SEVERE' named entity 'COMMENTARY' named entity 'PATIENTS' named entity 'LOWER RESPIRATORY TRACT' named entity 'VIRUS' named entity 'PAGES' covid:arg/2773edf2734f65d63b4c83a727bbda6d3f23c380 named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'EDITORIAL' named entity 'VENTILATED' named entity 'FINDINGS' named entity 'viruses' named entity 'enterovirus' named entity 'serum creatinine' named entity 'M. pneumoniae' named entity 'bronchoscopic' named entity 'SCAP' named entity 'SCAP' named entity 'real-time PCR' named entity 'septic shock' named entity 'viruses' named entity 'Purulent' named entity 'multiplex PCR' named entity 'PCR' named entity 'ICUs' named entity 'viral infection' named entity 'virus' named entity 'intensive care' named entity 'alcoholism' named entity 'SCAP' named entity 'PCR' named entity 'antibody' named entity 'edema' named entity 'PCR test' named entity 'influenza' named entity 'etiology' named entity 'Streptococcus pneumoniae' named entity 'virus' named entity 'viral infections' named entity 'chronic pulmonary disease' named entity 'serum samples' named entity 'SCAP' named entity 'infection' named entity 'blood culture' named entity '57.7%' named entity 'pneumonia' named entity 'SCAP' named entity 'SCAP' named entity 'procalcitonin' named entity 'lower respiratory tract' named entity 'SCAP' named entity 'staining' named entity 'viral infection' named entity 'urine' named entity 'urine sample' named entity 'etiology' named entity 'viral infection' named entity 'C. pneumoniae' named entity 'lower respiratory tract' named entity 'Chronic Health' named entity 'pleural' named entity 'rhinovirus' named entity 'urine' named entity 'septic shock' named entity 'SCAP' named entity 'coinfections' named entity 'SCAP' named entity 'pneumococcal' named entity 'Etiological' named entity 'CAP' named entity 'ICU' named entity 'Commentary' named entity 'Virus' named entity 'intubation' named entity 'SCAP' named entity 'respiratory rate'

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