About: Design, Synthesis, and Bioevaluation of Viral 3C and 3C-Like Protease Inhibitors

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About: Design, Synthesis, and Bioevaluation of Viral 3C and 3C-Like Protease Inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Design, Synthesis, and Bioevaluation of Viral 3C and 3C-Like Protease Inhibitors
Creator	Chang, Kyeong-Ok Kim, Yunjeong Weerasekara, Sahani Groutas, William Alliston, Kevin Hua, Duy Moroze, Meghan Prior, Allan Uy, Roxanne
Source	Elsevier; Medline; PMC
abstract	A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, α-ketoamide, bisulfite adduct, and α-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities.
has issue date	2013-12-01(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2013.09.070
bibo:pmid	24125888
has license	green-oa
sha1sum (hex)	278346f96e825556eda1be7ff6bd64de6b314a9f
schema:url	https://doi.org/10.1016/j.bmcl.2013.09.070
resource representing a document's title	Design, Synthesis, and Bioevaluation of Viral 3C and 3C-Like Protease Inhibitors
has PubMed Central identifier	PMC3863581
has PubMed identifier	24125888
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:278346f96e825556eda1be7ff6bd64de6b314a9f#body_text
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