About: Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice

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About: Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice
Creator	Mantovani, Alberto Pesenti, Antonio Garlanda, Cecilia Doni, Andrea Bellani, Giacomo Biondi, Andrea Cappuzzello, Claudia Castiglioni, Vittoria Dander, Erica Mauri, Tommaso Sironi, Marina Zambelli, Vanessa D'amico, Giovanna
Source	Medline; PMC
abstract	BACKGROUND: Mesenchymal stem cells (MSCs) might act as fine-tuners of inflammation during acute lung injury. We assessed the effects of adoptive transfer of MSCs in acid aspiration acute lung injury and explored the role of long pentraxin PTX3. METHODS: We conducted a prospective experimental interventional study on wild-type (WT) and PTX3-deficient (PTX3(−/−)) mice. Acute lung injury was induced in WT and PTX3(−/−) mice by instillation of hydrochloric acid into the right bronchus. One hour later, animals received intraperitoneal sterile phosphate-buffered saline (PBS), WT-MSCs (1 × 10(6)) or PTX3(−/−)-MSCs (1 × 10(6)). Twenty-four hours after injury, we measured the effects of treatments on arterial blood gases, wet/dry lung weight (W/D), CT scan analysis of lung collapse, neutrophils, TNFα and CXCL1 in bronchoalveolar lavage, and plasma PTX3. d-dimer was assayed in 1 week and OH-proline in 2 weeks to track the fibrotic evolution. RESULTS: In 24 h, in comparison to PBS, WT-MSCs improved oxygenation and reduced W/D and alveolar collapse. These effects were associated with decreased concentrations of alveolar neutrophils and cytokines. WT-MSCs increased d-dimer concentration and decreased OH-proline levels, too. Treatment with PTX3(−/−)-MSCs ameliorated oxygenation, W/D, and alveolar TNFα, though to a lesser extent than WT-MSCs. PTX3(−/−)-MSCs did not improve lung collapse, neutrophil count, CXCL1, d-dimer, and OH-proline concentrations. The protective effects of WT-MSCs were dampened by lack of endogenous PTX3, too. CONCLUSIONS: In acid aspiration acute lung injury, MSCs improve pulmonary function and limit fibrosis by fine-tuning inflammation. The role of PTX3 in determining MSCs’ effects might merit further scrutiny. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40635-017-0126-5) contains supplementary material, which is available to authorized users.
has issue date	2017-03-06(xsd:dateTime)
bibo:doi	10.1186/s40635-017-0126-5
bibo:pmid	28265979
has license	cc-by
sha1sum (hex)	2786687808083b1a23083be32dae8229ff545179
schema:url	https://doi.org/10.1186/s40635-017-0126-5
resource representing a document's title	Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice
has PubMed Central identifier	PMC5339261
has PubMed identifier	28265979
schema:publication	Intensive Care Med Exp
resource representing a document's body	covid:2786687808083b1a23083be32dae8229ff545179#body_text
is schema:about of	named entity 'MSCs' named entity 'oxygenation' named entity 'long' named entity 'Methods' named entity 'concentration' named entity 'Mesenchymal stem cells' named entity 'acute lung injury' named entity 'PBS' named entity 'TO TRACK' named entity 'LESSER' named entity 'TREATMENTS' named entity 'RESULTS' named entity 'ANALYSIS' named entity 'ASSOCIATED WITH' named entity 'ALVEOLAR' named entity 'CONCENTRATIONS' named entity 'SALINE' named entity 'ACUTE LUNG INJURY' named entity 'FIBROSIS' named entity 'EXPERIMENTAL' named entity 'CYTOKINES' named entity 'LEVELS' named entity 'TWENTY-FOUR' named entity 'HOURS' named entity 'WET' named entity 'HYDROCHLORIC ACID' named entity 'D-DIMER' named entity 'DID' named entity 'IMPROVED' named entity 'PROSPECTIVE' named entity 'NEUTROPHIL COUNT' named entity 'LUNG COLLAPSE' named entity 'INCREASED' named entity 'MESENCHYMAL STEM CELLS' named entity 'CONCLUSIONS' named entity 'BUFFERED' named entity 'ACUTE LUNG INJURY' named entity 'ACT' named entity 'MICE' named entity 'MESENCHYMAL STEM CELLS' named entity 'ONE HOUR' named entity 'MEASURED' named entity 'RECEIVED' named entity '1 WEEK' named entity 'ACID ASPIRATION' named entity 'SCRUTINY' named entity 'LATER' named entity 'FINE' named entity 'DECREASED' named entity 'RIGHT BRONCHUS' named entity 'CXCL1' named entity 'MICE' named entity 'INTERVENTIONAL STUDY' named entity 'PBS' named entity 'OH-' named entity 'ADOPTIVE TRANSFER' named entity 'OXYGENATION' named entity 'CT SCAN' named entity 'BACKGROUND' named entity 'INTRAPERITONEAL' named entity '2 WEEKS' named entity 'LUNG WEIGHT' named entity 'LONG' named entity 'METHODS' named entity 'MSCS' named entity 'CONCENTRATION' named entity 'ACID ASPIRATION' named entity 'COLLAPSE' named entity 'WILDTYPE'

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