About: ''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?''

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: ''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?'' Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?''
Creator	Associate, Cengiz, Mahir Ikitimur, Hande Ozcan, Erkan Sami Islamoglu, Mehmet Seyhan, Serhat Uysal, Betul Uysal, Harun Yavuzer, Serap Yavuzer, Hakan
source	Medline; PMC
abstract	OBJECTIVE: In this study, we report a large family cluster consisting of 29 genetically related patients hospitalized with COVID‐19. We sought to determine the clinical characteristics relevant to the clinical course of COVID‐19 by comparing the family cluster to unrelated patients with SARS‐CoV‐2 infection so that the presence of potential determinants of disease severity, other than traditional risk factors previously reported, could be investigated. METHODS: 29 patient files were investigated in Group 1 and Group 2 was created with 52 consecutive COVID‐19 patients with age and gender compatibility. The virus was detected for diagnosis. The clinical, laboratory and imaging features of all patients were retrospectively screened. Disease course was assessed using records regarding outcome from patient files retrospectively. Groups were compared with respect to baseline characteristics, disease severity on presentation, disease course. RESULTS: There was no difference between the two groups in terms of comorbidity and smoking history. In terms of in‐hospital treatment, use differed not significantly between two groups. We found that all 29 patients in Group 1 had severe pneumonia, 18 patients had severe pneumonia. Hospitalization rates, length of hospital stay and transferred to ICU were found to be statistically significantly higher in Group 1. CONCLUSION: In the present study, COVID‐19 cases in the large family cluster were shown to have more severe disease and worse clinical course compared to consecutive COVID‐19 patients presenting to the same time. We believe further studies into potential genetic mechanisms of host susceptibility to COVID‐19 should include such family clusters. This article is protected by copyright. All rights reserved.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.1002/jmv.26106
bibo:pmid	32492209
has license	no-cc
sha1sum (hex)	2789bf98fac65a1410f81c1dede12bb078b99af4
schema:url	https://doi.org/10.1002/jmv.26106
resource representing a document's title	''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?''
has PubMed Central identifier	PMC7300487
has PubMed identifier	32492209
schema:publication	J Med Virol
resource representing a document's body	covid:2789bf98fac65a1410f81c1dede12bb078b99af4#body_text
is schema:about of	named entity 'COVID-19' named entity 'COVID-19' named entity 'traditional' named entity 'large' named entity 'disease' named entity 'Genetic' named entity 'Patients' named entity 'infection' named entity 'risk factors' named entity 'Host Factors' named entity 'COVID' named entity 'hospital stays' named entity 'physical findings' named entity 'clinical outcome' named entity 'underlying diseases' named entity 'COVID-19' named entity 'biochemistry' named entity 'D-Dimer' named entity 'comorbidities' named entity 'COVID-19' named entity 'co-morbidities' named entity 'CT examinations' named entity 'antiviral treatment' named entity 'plasma' named entity 'clinical outcomes' named entity 'diabetes mellitus' named entity 'COVID' named entity 'COVID' named entity 'university hospital' named entity 'genetic mechanisms' named entity 'retrospective study' named entity 'Troponin' named entity 'Renin-Angiotensin-Aldosterone' named entity 'COVID' named entity 'COVID-19' named entity 'clinically significant' named entity 'co-morbid' named entity 'Angiotensin Receptor blockers' named entity 'older people' named entity 'lopinavir' named entity 'COVID' named entity 'COVID' named entity 'chronic respiratory disease' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'antibiotics' named entity 'COVID-19' named entity 'statistically significantly' named entity 'triage' named entity '23.5%' named entity 'ICU' named entity 'Genetic factors' named entity 'comorbid conditions' named entity 'Student's t-test' named entity 'COVID' named entity 'prognosis' named entity 'RAAS' named entity 'CHD' named entity 'statistically significant' named entity 'COVID-19' named entity 'COVID' named entity 'CRP' named entity 'SARS-CoV' named entity 'infection' named entity 'statistical significance' named entity 'Angiotensin Converting Enzyme' named entity 'droplet transmission' named entity 'COVID' named entity 'COVID' named entity 'nasopharyngeal swab' named entity 'COVID' named entity 'demographic information'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software