About: Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts
Creator	Vlasova, Anastasia Lager, Kelly Saif, Linda Langel, Stephanie Paim, Francine
Source	Elsevier; Medline; PMC
abstract	Abstract Morbidity, mortality, and loss of productivity from enteric diseases in neonatal piglets cost swine producers millions of dollars annually. In 2013–2014, the porcine epidemic diarrhea virus (PEDV) outbreak led to $900 million to $1.8 billion in annual losses to US swine producers. Passive lactogenic immunity remains the most promising and effective way to protect neonatal suckling piglets from enteric diseases like PEDV. Protecting suckling piglets through lactogenic immunity is dependent on trafficking of pathogen-specific IgA plasmablasts to the mammary gland and accumulation of secretory IgA (sIgA) antibodies in milk, defined as the gut-mammary-sIgA axis. Due to an impermeable placenta, piglets are born agammaglobulinic, and are highly susceptible to a plethora of infectious agents. They rely solely on colostrum and milk antibodies for maternal lactogenic immunity. Previous advances in the development of live and attenuated vaccines for another devastating diarrheal virus of pigs, transmissible gastroenteritis virus (TGEV), provide insights into the mechanisms of maternal immunity and piglet protection. In this chapter, we will review previous research on TGEV-induced lactogenic immunity to provide a historical perspective on current efforts for PEDV control and vaccines in the swine industry. Identifying factors that influence lactogenic immunity and the gut-mammary-sIgA axis may lead to improved vaccine regimens for PEDV and other enteric pathogens in gestating swine and improved overall herd immunity, swine health and industry productivity.
has issue date	2016-12-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2016.05.016
bibo:pmid	27212686
has license	els-covid
sha1sum (hex)	27b2c6072c3f0ea86e1cb4c527a825e73a56cc4e
schema:url	https://doi.org/10.1016/j.virusres.2016.05.016
resource representing a document's title	Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts
has PubMed Central identifier	PMC7111331
has PubMed identifier	27212686
schema:publication	Virus Research
resource representing a document's body	covid:27b2c6072c3f0ea86e1cb4c527a825e73a56cc4e#body_text
is schema:about of	named entity 'virus' named entity 'immunity' named entity 'Identifying' named entity 'mammary gland' named entity 'attenuated' named entity 'antibodies' named entity 'transmissible' named entity 'VACCINES' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'THE GUT' named entity 'OUTBREAK' named entity 'AXIS' named entity 'EFFECTIVE' named entity 'CONTROL' named entity 'PIGLET' named entity 'MATERNAL' named entity 'SIGA' named entity 'MECHANISMS' named entity 'LIKE' named entity '24900' named entity 'IGA' named entity 'RESEARCH' named entity 'PLETHORA' named entity 'CHAPTER' named entity 'ANNUAL' named entity 'MAMMARY' named entity 'MILLION' named entity 'IDENTIFYING' named entity 'DEFINED' named entity 'MAMMARY GLAND' named entity 'VACCINES' named entity 'HERD IMMUNITY' named entity 'DEVELOPMENT' named entity 'DEPENDENT' named entity 'PRODUCERS' named entity 'INDUCED' named entity 'TO PROVIDE' named entity 'INDUSTRY' named entity 'ANNUALLY' named entity 'LIVE' named entity 'ANTIBODIES' named entity 'LED' named entity 'ATTENUATED VACCINES' named entity 'TRAFFICKING' named entity 'MORTALITY' named entity 'PASSIVE' named entity 'IMMUNITY' named entity 'MORBIDITY' named entity 'COST' named entity 'HISTORICAL' named entity 'VACCINE' named entity 'SECRETORY IGA' named entity 'CONCEPTS' named entity 'COLOSTRUM' named entity 'IMPROVED' named entity 'PROVIDE' named entity 'SPECIFIC' named entity 'HEALTH' covid:arg/27b2c6072c3f0ea86e1cb4c527a825e73a56cc4e named entity 'HIGHLY' named entity 'REVIEW' named entity 'IMMUNITY' named entity 'INFECTIOUS AGENTS' named entity 'PROTECTING' named entity 'MILK' named entity 'NEONATAL' named entity 'SWINE' named entity 'DISEASES' named entity 'PREVIOUS' named entity 'LOSS OF' named entity 'INSIGHTS' named entity 'SUSCEPTIBLE' named entity 'REGIMENS' named entity 'ENTERIC' named entity 'WAY' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PATHOGEN'

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