About: Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of Escherichia coli as a mucosal vaccine

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About: Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of Escherichia coli as a mucosal vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of Escherichia coli as a mucosal vaccine
Creator	Hahn, Tae-Wook Jang, Jisung Do, Van Kim, Kiju Dao, Thu Hoai, · Park, Jeongho
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) targets the intestinal mucosa in pigs. To protect against PEDV invasion, a mucosal vaccine is utilized effectively. In this study, we generated a recombinant adenovirus vaccine encoding the heat-labile enterotoxin B (LTB) and the core neutralizing epitope (COE) of PEDV (rAd-LTB-COE). The fusion protein LTB-COE was successfully expressed by the recombinant adenovirus in HEK293 cells, and the immunogenicity of the vaccine candidate was assessed in BALB/c mice and piglets. Three intramuscular or oral vaccinations with rAd-LTB-COE at two-week intervals induced robust humoral and mucosal immune responses. Moreover, a cell-mediated immune response was promoted in immunized mice, and the neutralizing antibody inhibited both the vaccine strain and the emerging PEDV isolate. Immunization experiments in piglets revealed that rAd-LTB-COE was immunogenic and induced good immune responses in piglets. Further studies are required to evaluate the efficacy of rAd-LTB-COE against a highly virulent PEDV challenge.
has issue date	2020-01-16(xsd:dateTime)
bibo:doi	10.1007/s00705-019-04492-7
bibo:pmid	31950289
has license	no-cc
sha1sum (hex)	27b5e440dae0a1a99d41de1870e1e0d30d76d732
schema:url	https://doi.org/10.1007/s00705-019-04492-7
resource representing a document's title	Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of Escherichia coli as a mucosal vaccine
has PubMed Central identifier	PMC7087028
has PubMed identifier	31950289
schema:publication	Arch Virol
resource representing a document's body	covid:27b5e440dae0a1a99d41de1870e1e0d30d76d732#body_text
is schema:about of	named entity 'pigs' named entity 'fusion protein' named entity 'inhibited' named entity 'epitope' named entity 'neutralizing' named entity 'adenovirus' named entity 'Escherichia coli' named entity 'EPITOPE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'TARGETS' named entity 'IMMUNE RESPONSES' named entity 'RAD' named entity 'IMMUNIZED' named entity 'ESCHERICHIA COLI' named entity 'LTB' named entity 'EPITOPE' named entity 'ASSESSED' named entity 'PROTEIN LTB' named entity 'VACCINATIONS' named entity 'BALB' named entity 'ENTEROTOXIN B' named entity 'COE' named entity 'EFFICACY' named entity 'IMMUNOGENIC' named entity 'INTERVALS' named entity 'CARRYING' named entity 'CELL-MEDIATED IMMUNE RESPONSE' named entity 'VACCINE CANDIDATE' named entity 'EVALUATE' named entity 'IMMUNIZATION' named entity 'NEUTRALIZING ANTIBODY' named entity 'INVASION' named entity 'MUCOSAL VACCINE' named entity 'ENTEROTOXIN B' named entity 'HEAT' named entity 'RECOMBINANT ADENOVIRUS' named entity 'CORE' named entity 'REQUIRED' named entity 'HEK293 CELLS' named entity 'INHIBITED' named entity 'GOOD' named entity 'CHALLENGE' named entity 'INTESTINAL MUCOSA' named entity 'ISOLATE' named entity 'VACCINE STRAIN' named entity 'GENERATED' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MUCOSAL' named entity 'EXPERIMENTS' named entity 'REVEALED' named entity 'IMMUNOGENICITY' named entity 'ORAL' named entity 'MICE' named entity 'WEEK' named entity 'HIGHLY' named entity 'INDUCED' named entity 'CORE' named entity 'STUDIES' named entity 'MUCOSAL VACCINE' named entity 'INTRAMUSCULAR' named entity 'ROBUST' named entity 'STUDY' named entity 'PIGS' named entity 'ADENOVIRUS VACCINE' named entity 'VIRULENT' named entity 'FUSION PROTEIN' named entity 'A CELL' named entity 'ENCODING' named entity 'RECOMBINANT ADENOVIRUS' named entity 'HEAT' named entity 'EXPRESSED' covid:arg/27b5e440dae0a1a99d41de1870e1e0d30d76d732 named entity 'immune responses' named entity 'candidate' named entity 'recombinant'

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